From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel

by Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga
Published 2018-05-01

2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4<i>H</i>-chromen-2-yl)phenyl (<i>E</i>)-3-(4-hydroxy-3-methoxyphenyl)acrylate: Synthesis, In Silico Analysis and In Vitro Pharmacological Evalu...

by Antonella Brizzi, Alfonso Trezza, Ottavia Spiga, Samuele Maramai, Francesco Scorzelli, Simona Saponara, Fabio Fusi
Published 2021-07-01

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

by Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova
Published 2019-05-01

Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease

by Ottavia Spiga, Vittoria Cicaloni, Cosimo Fiorini, Alfonso Trezza, Anna Visibelli, Lia Millucci, Giulia Bernardini, Andrea Bernini, Barbara Marzocchi, Daniela Braconi, Filippo Prischi, Annalisa Santucci
Published 2020-02-01