Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions

by Alessandro Alaimo, Alvaro Villarroel
Published 2018-07-01

Atomistic Insights of Calmodulin Gating of Complete Ion Channels

by Eider Núñez, Arantza Muguruza-Montero, Alvaro Villarroel
Published 2020-02-01

The Crossroad of Ion Channels and Calmodulin in Disease

by Janire Urrutia, Alejandra Aguado, Arantza Muguruza-Montero, Eider Núñez, Covadonga Malo, Oscar Casis, Alvaro Villarroel
Published 2019-01-01

Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin

by Alvaro Villarroel, Carolina Gomis-Perez, Maria V. Soldovieri, Covadonga Malo, Paolo Ambrosino, Maurizio Taglialatela, Maurizio Taglialatela, Pilar Areso
Published 2017-05-01

Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

by Alessandro Alaimo, Araitz Alberdi, Carolina Gomis-Perez, Juncal Fernández-Orth, Ganeko Bernardo-Seisdedos, Covadonga Malo, Oscar Millet, Pilar Areso, Alvaro Villarroel
Published 2014-01-01

Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

by Pedro A. Lazo, Juan L. García, Paulino Gómez-Puertas, Íñigo Marcos-Alcalde, Cesar Arjona, Alvaro Villarroel, Rogelio González-Sarmiento, Carmen Fons
Published 2020-06-01

Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity.

by Noa Regev, Nurit Degani-Katzav, Alon Korngreen, Adi Etzioni, Sivan Siloni, Alessandro Alaimo, Dodo Chikvashvili, Alvaro Villarroel, Bernard Attali, Ilana Lotan
Published 2009-08-01

Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker.

by Paloma Aivar, Juncal Fernández-Orth, Carolina Gomis-Perez, Araitz Alberdi, Alessandro Alaimo, Manuel S Rodríguez, Teresa Giraldez, Pablo Miranda, Pilar Areso, Alvaro Villarroel
Published 2012-01-01

Correction: Kv7 Channels Can Function without Constitutive Calmodulin Tethering

by Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel
Published 2014-01-01

Kv7 channels can function without constitutive calmodulin tethering.

by Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel
Published 2011-01-01

Correction: Kv7 Channels Can Function without Constitutive Calmodulin Tethering.

by Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel
Published 2014-01-01

An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

by Janire Urrutia, Alejandra Aguado, Carolina Gomis-Perez, Arantza Muguruza-Montero, Oscar R. Ballesteros, Jiaren Zhang, Eider Nuñez, Covadonga Malo, Hee Jung Chung, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
Published 2021-05-01

Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

by Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi
Published 2020-12-01