The Intersection of Age and Influenza Severity: Utility of Ferrets for Dissecting the Age-Dependent Immune Responses and Relevance to Age-Specific Vaccine Development

by Melissa Rioux, Magen E. Francis, Cynthia L. Swan, Anni Ge, Andrea Kroeker, Alyson A. Kelvin
Published 2021-04-01

The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?

by Melissa Rioux, Mara McNeil, Magen E. Francis, Nicholas Dawe, Mary Foley, Joanne M. Langley, Alyson A. Kelvin
Published 2020-09-01

Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets.

by Stephen S H Huang, David Banner, Yuan Fang, Derek C K Ng, Thirumagal Kanagasabai, David J Kelvin, Alyson A Kelvin
Published 2011-01-01

Historical H1N1 Influenza Virus Imprinting Increases Vaccine Protection by Influencing the Activity and Sustained Production of Antibodies Elicited at Vaccination in Ferrets

by Magen E. Francis, Mara McNeil, Nicholas J. Dawe, Mary K. Foley, Morgan L. King, Ted M. Ross, Alyson A. Kelvin
Published 2019-09-01

Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses.

by Stéphane G Paquette, David Banner, Stephen S H Huang, Raquel Almansa, Alberto Leon, Luoling Xu, Jessica Bartoszko, David J Kelvin, Alyson A Kelvin
Published 2015-10-01

Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

by Magen E. Francis, Brian Richardson, Una Goncin, Mara McNeil, Melissa Rioux, Mary K. Foley, Anni Ge, Roger D. Pechous, Jason Kindrachuk, Cheryl M. Cameron, Christopher Richardson, Jocelyne Lew, Steven Machtaler, Mark J. Cameron, Volker Gerdts, Darryl Falzarano, Alyson A. Kelvin
Published 2021-07-01

Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity.

by Alyson A Kelvin, David Banner, Giuliano Silvi, Maria Luisa Moro, Nadir Spataro, Paolo Gaibani, Francesca Cavrini, Anna Pierro, Giada Rossini, Mark J Cameron, Jesus F Bermejo-Martin, Stéphane G Paquette, Luoling Xu, Ali Danesh, Amber Farooqui, Ilaria Borghetto, David J Kelvin, Vittorio Sambri, Salvatore Rubino
Published 2011-08-01

Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection...

by Mary K. Foley, Samuel D. Searle, Ali Toloue, Ryan Booth, Alec Falkenham, Darryl Falzarano, Salvatore Rubino, Magen E. Francis, Mara McNeil, Christopher Richardson, Jason LeBlanc, Sharon Oldford, Volker Gerdts, Melissa K. Andrew, Shelly A. McNeil, Barry Clarke, Kenneth Rockwood, David J. Kelvin, Alyson A. Kelvin
Published 2021-07-01

Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model.

by Mark J Cameron, Alyson A Kelvin, Alberto J Leon, Cheryl M Cameron, Longsi Ran, Luoling Xu, Yong-Kyu Chu, Ali Danesh, Yuan Fang, Qianjun Li, Austin Anderson, Ronald C Couch, Stephane G Paquette, Ndingsa G Fomukong, Otfried Kistner, Manfred Lauchart, Thomas Rowe, Kevin S Harrod, Colleen B Jonsson, David J Kelvin
Published 2012-01-01

Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection.

by Stéphane G Paquette, David Banner, Zhen Zhao, Yuan Fang, Stephen S H Huang, Alberto J Leόn, Derek C K Ng, Raquel Almansa, Ignacio Martin-Loeches, Paula Ramirez, Lorenzo Socias, Ana Loza, Jesus Blanco, Paola Sansonetti, Jordi Rello, David Andaluz, Bianche Shum, Salvatore Rubino, Raul Ortiz de Lejarazu, Dat Tran, Giovanni Delogu, Giovanni Fadda, Sigmund Krajden, Barry B Rubin, Jesús F Bermejo-Martin, Alyson A Kelvin, David J Kelvin
Published 2012-01-01

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

by Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo, Antonio Orduña, Raúl Méndez, Isabel Fernández Natal, Gregoria Megías, Montserrat González-Estecha, Demetrio Carriedo, Cristina Doncel, Noelia Jorge, Alicia Ortega, Amanda de la Fuente, Félix del Campo, José Antonio Fernández-Ratero, Wysali Trapiello, Paula González-Jiménez, Guadalupe Ruiz, Alyson A. Kelvin, Ali Toloue Ostadgavahi, Ruth Oneizat, Luz María Ruiz, Iria Miguéns, Esther Gargallo, Ioana Muñoz, Sara Pelegrin, Silvia Martín, Pablo García Olivares, Jamil Antonio Cedeño, Tomás Ruiz Albi, Carolina Puertas, Jose Ángel Berezo, Gloria Renedo, Rubén Herrán, Juan Bustamante-Munguira, Pedro Enríquez, Ramón Cicuendez, Jesús Blanco, Jesica Abadia, Julia Gómez Barquero, Nuria Mamolar, Natalia Blanca-López, Luis Jorge Valdivia, Belén Fernández Caso, María Ángeles Mantecón, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Ferrán Barbé, Antoni Torres, Rosario Menéndez, José María Eiros, David J. Kelvin
Published 2020-12-01