Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

by Manoranjenni Chetty, Theresa Cain, Janak Wedagedera, Amin Rostami-Hodjegan, Amin Rostami-Hodjegan, Masoud Jamei
Published 2018-03-01

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

by Amin Rostami‐Hodjegan, Frederic Y. Bois
Published 2021-05-01

Precision medicine technology hype or reality? The example of computer-guided dosing [version 1; peer review: 2 approved]

by Thomas M. Polasek, Sepehr Shakib, Amin Rostami-Hodjegan
Published 2019-10-01

Precision medicine technology reality not hype - The example of model-informed precision dosing [version 2; peer review: 2 approved]

by Thomas M. Polasek, Sepehr Shakib, Amin Rostami-Hodjegan
Published 2019-12-01

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

by Hiroyuki Takita, Adam S. Darwich, Amais Ahmad, Amin Rostami‐Hodjegan
Published 2020-11-01

Precision dosing to avoid adverse drug reactions

by Thomas M. Polasek, Carl M. J. Kirkpatrick, Amin Rostami-Hodjegan
Published 2019-12-01

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

by Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2021-05-01

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-05-01

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

by Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Published 2020-06-01