Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

by Ewan P. Plant, Deborah R. Taylor, Jonathan D. Dinman, Ralph S. Baric, Amy C. Sims
Published 2013-01-01

Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

by Aartjan J W te Velthuis, Sjoerd H E van den Worm, Amy C Sims, Ralph S Baric, Eric J Snijder, Martijn J van Hemert
Published 2010-01-01

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

by Joshua M. Thornbrough, Babal K. Jha, Boyd Yount, Stephen A. Goldstein, Yize Li, Ruth Elliott, Amy C. Sims, Ralph S. Baric, Robert H. Silverman, Susan R. Weiss
Published 2016-03-01

Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung

by Fuyi Xu, Jun Gao, Jun Gao, Silke Bergmann, Amy C. Sims, David G. Ashbrook, Ralph S. Baric, Ralph S. Baric, Yan Cui, Colleen B. Jonsson, Kui Li, Robert W. Williams, Klaus Schughart, Klaus Schughart, Klaus Schughart, Lu Lu
Published 2021-01-01

The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections

by Hugh D. Mitchell, Amie J. Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Ji Wen, Jason E. McDermott, Lisa E. Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Katrina M. Waters
Published 2019-09-01

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

by Vineet D. Menachery, Lisa E. Gralinski, Hugh D. Mitchell, Kenneth H. Dinnon, Sarah R. Leist, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Kelly G. Stratton, Adam S. Cockrell, Kari Debbink, Amy C. Sims, Katrina M. Waters, Ralph S. Baric, Ana Fernandez-Sesma
Published 2017-11-01

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

by Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison, Kanta Subbarao
Published 2018-03-01

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

by Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Published 2020-01-01

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

by Ernesto S. Nakayasu, Carrie D. Nicora, Amy C. Sims, Kristin E. Burnum-Johnson, Young-Mo Kim, Jennifer E. Kyle, Melissa M. Matzke, Anil K. Shukla, Rosalie K. Chu, Athena A. Schepmoes, Jon M. Jacobs, Ralph S. Baric, Bobbie-Jo Webb-Robertson, Richard D. Smith, Thomas O. Metz, Nicholas Chia
Published 2016-05-01

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.

by Hugh D Mitchell, Amie J Eisfeld, Amy C Sims, Jason E McDermott, Melissa M Matzke, Bobbi-Jo M Webb-Robertson, Susan C Tilton, Nicolas Tchitchek, Laurence Josset, Chengjun Li, Amy L Ellis, Jean H Chang, Robert A Heegel, Maria L Luna, Athena A Schepmoes, Anil K Shukla, Thomas O Metz, Gabriele Neumann, Arndt G Benecke, Richard D Smith, Ralph S Baric, Yoshihiro Kawaoka, Michael G Katze, Katrina M Waters
Published 2013-01-01

Hypergraph models of biological networks to identify genes critical to pathogenic viral response

by Song Feng, Emily Heath, Brett Jefferson, Cliff Joslyn, Henry Kvinge, Hugh D. Mitchell, Brenda Praggastis, Amie J. Eisfeld, Amy C. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, Timothy P. Sheahan, Adam S. Cockrell, Jacob F. Kocher, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Michael S. Diamond, Ralph S. Baric, Katrina M. Waters, Yoshihiro Kawaoka, Jason E. McDermott, Emilie Purvine
Published 2021-05-01