Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

by Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Corinne M Walsh, Daniel J Snyder, Vaughn S Cooper, William M Old, Shelley D Copley
Published 2019-12-01

Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme.

by JohnCarlo Kristofich, Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Daniel J Snyder, William M Old, Vaughn S Cooper, Shelley D Copley
Published 2018-08-01