ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

by Winnie Tan, Winnie Tan, Sylvie van Twest, Vincent J. Murphy, Andrew J. Deans, Andrew J. Deans
Published 2020-02-01

Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer

by Paolo Peterlongo, Gisella Figlioli, Andrew J. Deans, Fergus J. Couch
Published 2021-09-01

ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

by Julienne J O’Rourke, Rohan Bythell-Douglas, Elyse A Dunn, Andrew J Deans
Published 2019-01-01

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.

by Wilson Castillo-Tandazo, Monique F Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Jörg Heierhorst, Andrew J Deans, Carl R Walkley
Published 2019-07-01

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

by Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin
Published 2019-05-01

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

by Paolo Swuec, Ludovic Renault, Aaron Borg, Fenil Shah, Vincent J. Murphy, Sylvie van Twest, Ambrosius P. Snijders, Andrew J. Deans, Alessandro Costa
Published 2017-01-01

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

by Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent J Murphy, Michael Sharp, Michael W Parker, Wayne Crismani, Andrew J Deans
Published 2020-03-01

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin.

by Winnie Tan, Vincent J Murphy, Aude Charron, Sylvie van Twest, Michael Sharp, Angelos Constantinou, Michael W Parker, Wayne Crismani, Rohan Bythell-Douglas, Andrew J Deans
Published 2020-01-01

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

by Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Published 2019-05-01

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

by Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Published 2019-11-01

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

by Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Published 2020-05-01