Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

by Anna Z. Wec, Kathy S. Lin, Jamie C. Kwasnieski, Sam Sinai, Jeff Gerold, Eric D. Kelsic, Eric D. Kelsic
Published 2021-04-01

Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability

by Laila Shehata, Daniel P. Maurer, Anna Z. Wec, Asparouh Lilov, Elizabeth Champney, Tingwan Sun, Kimberly Archambault, Irina Burnina, Heather Lynaugh, Xiaoyong Zhi, Yingda Xu, Laura M. Walker
Published 2019-09-01

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

by Katie A. Howell, Xiangguo Qiu, Jennifer M. Brannan, Christopher Bryan, Edgar Davidson, Frederick W. Holtsberg, Anna Z. Wec, Sergey Shulenin, Julia E. Biggins, Robin Douglas, Sven G. Enterlein, Hannah L. Turner, Jesper Pallesen, Charles D. Murin, Shihua He, Andrea Kroeker, Hong Vu, Andrew S. Herbert, Marnie L. Fusco, Elisabeth K. Nyakatura, Jonathan R. Lai, Zhen-Yong Keck, Steven K.H. Foung, Erica Ollmann Saphire, Larry Zeitlin, Andrew B. Ward, Kartik Chandran, Benjamin J. Doranz, Gary P. Kobinger, John M. Dye, M. Javad Aman
Published 2016-05-01