Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening.

by Thomas Coudrat, Arthur Christopoulos, Patrick Michael Sexton, Denise Wootten
Published 2017-01-01

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

by Thomas Coudrat, John Simms, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Published 2017-11-01

Correspondence: Reply to ‘Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury’

by Cheng Xue Qin, Lauren T. May, Patrick M. Sexton, Aaron J. DeBono, Jonathan B. Baell, Arthur Christopoulos, Rebecca H. Ritchie
Published 2018-02-01

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.

by Kim Vietz Andreassen, Sara Toftegaard Hjuler, Sebastian G Furness, Patrick M Sexton, Arthur Christopoulos, Olivier Nosjean, Morten Asser Karsdal, Kim Henriksen
Published 2014-01-01

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

by Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos
Published 2021-01-01

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

by Patricia Rueda, Jon Merlin, Stefano Chimenti, Michel Feletou, Jerome Paysant, Paul J. White, Arthur Christopoulos, Patrick M. Sexton, Roger J. Summers, William N. Charman, Lauren T. May, Christopher J. Langmead
Published 2021-03-01

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse ColonSummary

by Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole
Published 2020-01-01

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

by Scott A. Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A. J. Venkatakrishnan, Samuel Hertig, Peter J. Scammells, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Ron O. Dror
Published 2019-07-01

The role of kinetic context in apparent biased agonism at GPCRs

by Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane
Published 2016-02-01

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.

by Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton
Published 2021-06-01

Structure and dynamics of the active Gs-coupled human secretin receptor

by Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Published 2020-08-01

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.

by Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N Charman, Arthur Christopoulos, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Published 2016-01-01

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

by Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli, Minh Deo, Amy E. Alexander, Duncan Horlock, Jane E. Bourke, Yuan H. Yang, Alastair G. Stewart, David M. Kaye, Xiao-Jun Du, Patrick M. Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H. Ritchie
Published 2017-02-01

A robust method for particulate detection of a genetic tag for 3D electron microscopy

by James Rae, Charles Ferguson, Nicholas Ariotti, Richard I Webb, Han-Hao Cheng, James L Mead, James D Riches, Dominic JB Hunter, Nick Martel, Joanne Baltos, Arthur Christopoulos, Nicole S Bryce, Maria Lastra Cagigas, Sachini Fonseka, Marcel E Sayre, Edna C Hardeman, Peter W Gunning, Yann Gambin, Thomas E Hall, Robert G Parton
Published 2021-04-01