An engineered viral protease exhibiting substrate specificity for a polyglutamine stretch prevents polyglutamine-induced neuronal cell death.

by Saravanan Sellamuthu, Bae Hyun Shin, Hye-Eun Han, Sang Min Park, Hye Jin Oh, Seong-Hwan Rho, Yong Jae Lee, Woo Jin Park
Published 2011-01-01

Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.

by Bae Hyun Shin, Yunki Lim, Hye Jin Oh, Sang Min Park, Sun-Kyung Lee, Joohong Ahnn, Do Han Kim, Woo Keun Song, Tae Hwan Kwak, Woo Jin Park
Published 2013-01-01

The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β.

by Hye-Eun Han, Saravanan Sellamuthu, Bae Hyun Shin, Yong Jae Lee, Sungmin Song, Ji-Seon Seo, In-Sun Baek, Jeomil Bae, Hannah Kim, Yung Joon Yoo, Yong-Keun Jung, Woo Keun Song, Pyung-Lim Han, Woo Jin Park
Published 2010-01-01