Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

by Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras Minhas, Matthew Pinto, Lee-Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, Guojun Bu, Benjamin Gateno, Kyeong-Ok Chang, Karl A. Nath, Emirhan Nemutlu, Petras Dzeja, Yuan-Ping Pang, Duy H. Hua, Eugenia Trushina
Published 2015-04-01

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

by Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Published 2021-01-01