Intergenerational epigenetic inheritance of cancer susceptibility in mammals

by Bluma J Lesch, Zuzana Tothova, Elizabeth A Morgan, Zhicong Liao, Roderick T Bronson, Benjamin L Ebert, David C Page
Published 2019-04-01

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

by Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer
Published 2018-08-01

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.

by Benjamin L Ebert, Naomi Galili, Pablo Tamayo, Jocelyn Bosco, Raymond Mak, Jennifer Pretz, Shyam Tanguturi, Christine Ladd-Acosta, Richard Stone, Todd R Golub, Azra Raza
Published 2008-02-01

Rapid and deep-scale ubiquitylation profiling for biology and translational research

by Namrata D. Udeshi, Deepak C. Mani, Shankha Satpathy, Shaunt Fereshetian, Jessica A. Gasser, Tanya Svinkina, Meagan E. Olive, Benjamin L. Ebert, Philipp Mertins, Steven A. Carr
Published 2020-01-01

Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

by Serena De Vita, Rebekka K Schneider, Michael Garcia, Jenna Wood, Mathilde Gavillet, Benjamin L Ebert, Alexander Gerbaulet, Axel Roers, Ross L Levine, Ann Mullally, David A Williams
Published 2014-01-01

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites

by Mónica S. Ventura Ferreira, Christian Bergmann, Isabelle Bodensiek, Kristina Peukert, Jessica Abert, Rafael Kramann, Paul Kachel, Björn Rath, Stephan Rütten, Ruth Knuchel, Benjamin L. Ebert, Horst Fischer, Tim H. Brümmendorf, Rebekka K. Schneider
Published 2016-01-01

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

by Ramprasad Ramakrishnan, Pablo Peña-Martínez, Puneet Agarwal, Maria Rodriguez-Zabala, Marion Chapellier, Carl Högberg, Mia Eriksson, David Yudovich, Mansi Shah, Mats Ehinger, Björn Nilsson, Jonas Larsson, Anna Hagström-Andersson, Benjamin L. Ebert, Ravi Bhatia, Marcus Järås
Published 2020-05-01

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

by Satish K Nandakumar, Sean K McFarland, Laura M Mateyka, Caleb A Lareau, Jacob C Ulirsch, Leif S Ludwig, Gaurav Agarwal, Jesse M Engreitz, Bartlomiej Przychodzen, Marie McConkey, Glenn S Cowley, John G Doench, Jaroslaw P Maciejewski, Benjamin L Ebert, David E Root, Vijay G Sankaran
Published 2019-05-01

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

by Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Benjamin L Ebert, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D Gary Gilliland, Ross L Levine
Published 2006-07-01

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML

by Zuzana Tothova, Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie Holmes, Catherine C. Landers, J. Erika Haydu, Edyta Malolepsza, Christina Hartigan, Melanie Donahue, Katerina D. Popova, Sebastian Koochaki, Sergey V. Venev, Jeanne Rivera, Edwin Chen, Kasper Lage, Monica Schenone, Alan D. D’Andrea, Steven A. Carr, Elizabeth A. Morgan, Job Dekker, Benjamin L. Ebert
Published 2021-02-01

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

by Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Published 2017-02-01

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

by Shrikanta Chattopadhyay, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Radhika Subramanian, Leigh C. Carmody, Rushdia Z. Yusuf, David B. Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D. Cirstea, Teru Hideshima, Vlado Dančík, Max M. Majireck, Mahmud M. Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J. Tolliday, Paul A. Clemons, Malcolm A.S. Moore, Andrew M. Stern, Alykhan F. Shamji, Benjamin L. Ebert, Todd R. Golub, Noopur S. Raje, David T. Scadden, Stuart L. Schreiber
Published 2015-02-01

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

by Tarek H. Mouhieddine, Adam S. Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H. Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Kalvis Hornburg, Henry Dumke, Muhieddine M. Itani, Cody J. Boehner, Chia-Jen Liu, Saud H. AlDubayan, Brendan Reardon, Eliezer M. Van Allen, Jonathan J. Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Lorenzo Trippa, Gad Getz, Donna S. Neuberg, Irene M. Ghobrial
Published 2020-06-01