Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

by Terri L. Petkau, Jake Blanco, Blair R. Leavitt
Published 2017-10-01

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

by Terri L. Petkau, Natalia Kosior, Kathleen de Asis, Colúm Connolly, Blair R. Leavitt
Published 2017-11-01

8OHdG as a marker for Huntington disease progression

by Jeffrey D. Long, Wayne R. Matson, Andrew R. Juhl, Blair R. Leavitt, Jane S. Paulsen
Published 2012-06-01

Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics

by Terri L. Petkau, Benjamin Life, Ge Lu, Jasmine Yang, Oriol Fornes, Wyeth Wasserman, Elizabeth M. Simpson, Blair R. Leavitt
Published 2021-06-01

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

by Sonia Franciosi, Jae K. Ryu, Yaein Shim, Austin Hill, Colum Connolly, Michael R. Hayden, James G. McLarnon, Blair R. Leavitt
Published 2012-01-01

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

by Jacqueline Shehadeh, Herman B. Fernandes, Melinda M. Zeron Mullins, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden, Lynn A. Raymond
Published 2006-02-01

Altered Intracortical T1-Weighted/T2-Weighted Ratio Signal in Huntington’s Disease

by Christopher D. Rowley, Sarah J. Tabrizi, Rachael I. Scahill, Blair R. Leavitt, Raymund A. C. Roos, Alexandra Durr, Alexandra Durr, Nicholas A. Bock
Published 2018-11-01

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

by Jeremy M. Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden
Published 2007-04-01

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

by Rona K. Graham, Elizabeth J. Slow, Yu Deng, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Blair R. Leavitt, Lynn A. Raymond, Michael R. Hayden
Published 2006-02-01

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington’s Disease

by Eileanoir B. Johnson, Sarah Gregory, Hans J. Johnson, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Raymund A. Roos, Geraint Rees, Sarah J. Tabrizi, Rachael I. Scahill
Published 2017-10-01

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

by Paolo Guidetti, Gillian P. Bates, Rona K. Graham, Michael R. Hayden, Blair R. Leavitt, Marcy E. MacDonald, Elizabeth J. Slow, Vanessa C. Wheeler, Ben Woodman, Robert Schwarcz
Published 2006-07-01

Utility of Huntington's Disease Assessments by Disease Stage: Floor/Ceiling Effects

by Daisy Abreu, Jennifer Ware, Nellie Georgiou-Karistianis, Blair R. Leavitt, Cheryl J. Fitzer-Attas, Raquel Lobo, Ana Raquel Fernandes, Olivia Handley, Karen E. Anderson, Julie C. Stout, Cristina Sampaio
Published 2021-07-01

Synaptic dysfunction in progranulin-deficient mice

by Terri L. Petkau, Scott J. Neal, Austen Milnerwood, Ada Mew, Austin M. Hill, Paul Orban, Jenny Gregg, Ge Lu, Howard H. Feldman, Ian R.A. Mackenzie, Lynn A. Raymond, Blair R. Leavitt
Published 2012-02-01

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models

by Ulrike Träger, Ralph Andre, Anna Magnusson-Lind, James R.C. Miller, Colúm Connolly, Andreas Weiss, Stephan Grueninger, Edina Silajdžić, Donna L. Smith, Blair R. Leavitt, Gillian P. Bates, Maria Björkqvist, Sarah J. Tabrizi
Published 2015-01-01

Testicular degeneration in Huntington disease

by Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, Ǻsa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt
Published 2007-06-01

Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease

by Lora Minkova, Sarah Gregory, Rachael I. Scahill, Ahmed Abdulkadir, Christoph P. Kaller, Jessica Peter, Jeffrey D. Long, Julie C. Stout, Ralf Reilmann, Raymund A. Roos, Alexandra Durr, Blair R. Leavitt, Sarah J. Tabrizi, Stefan Klöppel
Published 2018-01-01

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

by Rebecca S. Devon, Claudia Schwab, Justin D. Topp, Paul C. Orban, Yu-zhou Yang, Terry D. Pape, Jeffrey R. Helm, Tara-Lynne Davidson, Daniel A. Rogers, Francois Gros-Louis, Guy Rouleau, Bruce F. Horazdovsky, Blair R. Leavitt, Michael R. Hayden
Published 2005-03-01

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes

by Marc Ciosi, Alastair Maxwell, Sarah A. Cumming, Davina J. Hensman Moss, Asma M. Alshammari, Michael D. Flower, Alexandra Durr, Blair R. Leavitt, Raymund A.C. Roos, Peter Holmans, Lesley Jones, Douglas R. Langbehn, Seung Kwak, Sarah J. Tabrizi, Darren G. Monckton
Published 2019-10-01

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models

by Jack Wuyang Jin, Xuelai Fan, Esther del Cid-Pellitero, Xing-Xing Liu, Limin Zhou, Chunfang Dai, Ebrima Gibbs, Wenting He, Hongjie Li, Xiaobin Wu, Austin Hill, Blair R. Leavitt, Neil Cashman, Lidong Liu, Jie Lu, Thomas M. Durcan, Zhifang Dong, Edward A. Fon, Yu Tian Wang
Published 2021-02-01

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

by Stefan Klöppel, Sarah Gregory, Elisa Scheller, Lora Minkova, Adeel Razi, Alexandra Durr, Raymund A.C. Roos, Blair R. Leavitt, Marina Papoutsi, G. Bernhard Landwehrmeyer, Ralf Reilmann, Beth Borowsky, Hans Johnson, James A. Mills, Gail Owen, Julie Stout, Rachael I. Scahill, Jeffrey D. Long, Geraint Rees, Sarah J. Tabrizi
Published 2015-10-01