Amino Acid Sequence Amino acid sequence Binding interface Clustering approach Counterfactual simulations Dyskeratosis Congenita Fetal Growth Retardation Functional properties Harmonin homology domains Hidden Markov models Humans Membrane Proteins Neurons Phylogenetic analysis Phylogenetic trees Phylogeny Profile HMM Profile hidden Markov model Protein interaction Proteins Screening Sequence analysis Usher syndrome amino acid sequence computer simulation discrete choice analysis dyskeratosis congenita expert opinion field experiment field method