Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.

by Min-Hyuk Yoo, Bradley A Carlson, Vadim N Gladyshev, Dolph L Hatfield
Published 2013-01-01

Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development

by Dolph L. Hatfield, Vadim N. Gladyshev, Petra A. Tsuji, Min-Hyuk Yoo, Bradley A. Carlson
Published 2009-09-01

Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA.

by Virginia Rodriguez, Sona Vasudevan, Akiko Noma, Bradley A Carlson, Jeffrey E Green, Tsutomu Suzuki, Settara C Chandrasekharappa
Published 2012-01-01

Deficiency in the 15 kDa Selenoprotein Inhibits Human Colon Cancer Cell Growth

by Ryuta Tobe, Min-Hyuk Yoo, Bradley A. Carlson, Salvador Naranjo-Suarez, Petra A. Tsuji, Cindy D. Davis
Published 2011-09-01

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

by Ryuta Tobe, Bradley A. Carlson, Petra A. Tsuji, Byeong Jae Lee, Vadim N. Gladyshev, Dolph L. Hatfield
Published 2015-11-01

Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice

by Petra A. Tsuji, Bradley A. Carlson, Christine B. Anderson, Harold E. Seifried, Dolph L. Hatfield, Michael T. Howard
Published 2015-08-01

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.

by Min-Hyuk Yoo, Xue-Ming Xu, Bradley A Carlson, Andrew D Patterson, Vadim N Gladyshev, Dolph L Hatfield
Published 2007-10-01

Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.

by Irem Uluisik, Alaattin Kaya, Dmitri E Fomenko, Huseyin C Karakaya, Bradley A Carlson, Vadim N Gladyshev, Ahmet Koc
Published 2011-01-01

HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.

by Salvador Naranjo-Suarez, Bradley A Carlson, Petra A Tsuji, Min-Hyuk Yoo, Vadim N Gladyshev, Dolph L Hatfield
Published 2012-01-01

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck diseas...

by Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik
Published 2009-08-01

Selenoproteins are essential for proper keratinocyte function and skin development.

by Aniruddha Sengupta, Ulrike F Lichti, Bradley A Carlson, Andrew O Ryscavage, Vadim N Gladyshev, Stuart H Yuspa, Dolph L Hatfield
Published 2010-08-01

Biosynthesis of selenocysteine on its tRNA in eukaryotes.

by Xue-Ming Xu, Bradley A Carlson, Heiko Mix, Yan Zhang, Kazima Saira, Richard S Glass, Marla J Berry, Vadim N Gladyshev, Dolph L Hatfield
Published 2007-01-01

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

by Yassin Mahdi, Xue-Ming Xu, Bradley A Carlson, Noelia Fradejas, Paul Günter, Doreen Braun, Eileen Southon, Lino Tessarollo, Dolph L Hatfield, Ulrich Schweizer
Published 2015-01-01

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

by Bradley A. Carlson, Ryuta Tobe, Elena Yefremova, Petra A. Tsuji, Victoria J. Hoffmann, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Marcus Conrad
Published 2016-10-01

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

by Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu
Published 2020-07-01

Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes

by Lucia A. Seale, Ashley N. Ogawa-Wong, Ligia M. Watanabe, Vedbar S. Khadka, Mark Menor, Daniel J. Torres, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Published 2021-01-01

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.

by Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis
Published 2012-01-01

The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.

by Petra A Tsuji, Bradley A Carlson, Min-Hyuk Yoo, Salvador Naranjo-Suarez, Xue-Ming Xu, Yiwen He, Esther Asaki, Harold E Seifried, William C Reinhold, Cindy D Davis, Vadim N Gladyshev, Dolph L Hatfield
Published 2015-01-01

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

by Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield
Published 2013-01-01