TGF-β Inhibition Improves Oncolytic Herpes Viroimmunotherapy in Murine Models of Rhabdomyosarcoma

by Brian Hutzen, Chun-Yu Chen, Pin-Yi Wang, Les Sprague, Hayley M. Swain, Julia Love, Joe Conner, Louis Boon, Timothy P. Cripe
Published 2017-12-01

Immunotherapeutic Challenges for Pediatric Cancers

by Brian Hutzen, Mohammed Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady
Published 2019-12-01

Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models

by Chun-Yu Chen, Pin-Yi Wang, Brian Hutzen, Les Sprague, Hayley M. Swain, Julia K. Love, Joseph R. Stanek, Louis Boon, Joe Conner, Timothy P. Cripe
Published 2017-05-01

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

by Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li, Jiayuh Lin
Published 2010-01-01

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.

by Li Lin, Brian Hutzen, Hsiu-Fang Lee, Zhengang Peng, Wenlong Wang, Chongqiang Zhao, Huey-Jen Lin, Duxin Sun, Pui-Kai Li, Chenglong Li, Hasan Korkaya, Max S Wicha, Jiayuh Lin
Published 2013-01-01

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment

by Nicholas L. Denton, Chun-Yu Chen, Brian Hutzen, Mark A. Currier, Thomas Scott, Brooke Nartker, Jennifer L. Leddon, Pin-Yi Wang, Rachelle Srinivas, Kevin A. Cassady, William F. Goins, Timothy P. Cripe
Published 2018-12-01

Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children

by Gregory K Friedman, Elizabeth A Beierle, George Yancey Gillespie, James M Markert, Alicia M Waters, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, Timothy P Cripe
Published 2015-01-01

Pediatric cancer gone viral. Part I: strategies for utilizing oncolytic herpes simplex virus-1 in children

by Timothy P Cripe, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, James M Markert, Alicia M Waters, George Yancey Gillespie, Elizabeth A Beierle, Gregory K Friedman
Published 2015-01-01