Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity.

by Collin R Elsea, Daniel A Roberts, Brian J Druker, Lisa J Wood
Published 2008-06-01

Outgrowth of a CSF3R-mutant clone drives a second myeloproliferative neoplasm in a chronic myeloid leukemia patient: a case report

by Sarah A. Carratt, Diana Brewer, Julia E. Maxson, Brian J. Druker, Theodore P. Braun
Published 2021-01-01

A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

by Xiaoxue Qiu, Guijie Guo, Ke Chen, Masaki Kashiwada, Brian J. Druker, Paul B. Rothman, Ji-Long Chen
Published 2012-06-01

A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.

by Kara J Johnson, Ian J Griswold, Thomas O'Hare, Amie S Corbin, Marc Loriaux, Michael W Deininger, Brian J Druker
Published 2009-10-01

Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia

by Kim-Hien T. Dao, Magdolna B. Solti, Julia E. Maxson, Elliott F. Winton, Richard D. Press, Brian J. Druker, Jeffrey W. Tyner
Published 2014-01-01

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.

by C James Chou, Thomas O'Hare, Sophie Lefebvre, David Alvarez, Jeffrey W Tyner, Christopher A Eide, Brian J Druker, Joel M Gottesfeld
Published 2008-01-01

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

by Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer
Published 2019-02-01

Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells

by Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer
Published 2019-03-01

Survey of activated FLT3 signaling in leukemia.

by Ting-lei Gu, Julie Nardone, Yi Wang, Marc Loriaux, Judit Villén, Sean Beausoleil, Meghan Tucker, Jon Kornhauser, Jianmin Ren, Joan MacNeill, Steven P Gygi, Brian J Druker, Michael C Heinrich, John Rush, Roberto D Polakiewicz
Published 2011-04-01

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

by Alyssa Carey, David K. Edwards, V, Christopher A. Eide, Laura Newell, Elie Traer, Bruno C. Medeiros, Daniel A. Pollyea, Michael W. Deininger, Robert H. Collins, Jeffrey W. Tyner, Brian J. Druker, Grover C. Bagby, Shannon K. McWeeney, Anupriya Agarwal
Published 2017-03-01

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

by Brian S. White, Suleiman A. Khan, Mike J. Mason, Muhammad Ammad-ud-din, Swapnil Potdar, Disha Malani, Heikki Kuusanmäki, Brian J. Druker, Caroline Heckman, Olli Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Cristina E. Tognon, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Published 2021-07-01

A precision medicine classification for treatment of acute myeloid leukemia in older patients

by Alice S. Mims, Jessica Kohlschmidt, Uma Borate, James S. Blachly, Shelley Orwick, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Deedra Nicolet, Krzysztof Mrόzek, Eytan Stein, Bhavana Bhatnagar, Richard M. Stone, Jonathan E. Kolitz, Eunice S. Wang, Bayard L. Powell, Amy Burd, Ross L. Levine, Brian J. Druker, Clara D. Bloomfield, John C. Byrd
Published 2021-06-01

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

by Haijiao Zhang, Samantha Savage, Anna Reister Schultz, Daniel Bottomly, Libbey White, Erik Segerdell, Beth Wilmot, Shannon K. McWeeney, Christopher A. Eide, Tamilla Nechiporuk, Amy Carlos, Rachel Henson, Chenwei Lin, Robert Searles, Hoang Ho, Yee Ling Lam, Richard Sweat, Courtney Follit, Vinay Jain, Evan Lind, Gautam Borthakur, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Jorge Cortes, Robert Collins, Daelynn R. Buelow, Sharyn D. Baker, Brian J. Druker, Jeffrey W. Tyner
Published 2019-01-01

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

by Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Published 2019-11-01