Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.

by Lauren K Dunn, Khalid S Mohammad, Pierrick G J Fournier, C Ryan McKenna, Holly W Davis, Maria Niewolna, Xiang Hong Peng, John M Chirgwin, Theresa A Guise
Published 2009-09-01

Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.

by Khalid S Mohammad, Carol G Chen, Guive Balooch, Elizabeth Stebbins, C Ryan McKenna, Holly Davis, Maria Niewolna, Xiang Hong Peng, Daniel H N Nguyen, Sophi S Ionova-Martin, John W Bracey, William R Hogue, Darren H Wong, Robert O Ritchie, Larry J Suva, Rik Derynck, Theresa A Guise, Tamara Alliston
Published 2009-01-01