Comparison of in situ and extraction-based methods for the detection of MET amplifications in solid tumors

by Carina Heydt, Ann-Kathrin Becher, Svenja Wagener-Ryczek, Markus Ball, Anne M. Schultheis, Simon Schallenberg, Vanessa Rüsseler, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2019-01-01

Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma

by Alexander Quaas, Carina Heydt, Florian Gebauer, Hakan Alakus, Heike Loeser, Reinhard Buettner, Axel Hillmer, Christiane Bruns, Sabine Merkelbach-Bruse, Thomas Zander, Peter Frommolt
Published 2019-01-01

Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

by Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2020-07-01

Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics.

by Carina Heydt, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Katharina König, Lukas Carl Heukamp, Hans-Ulrich Schildhaus, Margarete Odenthal, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2014-01-01

MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas.

by Katja Schmitz, Hartmut Koeppen, Elke Binot, Jana Fassunke, Helen Künstlinger, Michaela A Ihle, Carina Heydt, Eva Wardelmann, Reinhard Büttner, Sabine Merkelbach-Bruse, Josef Rüschoff, Hans-Ulrich Schildhaus
Published 2015-01-01

Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

by Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner, Sabine Merkelbach-Bruse
Published 2020-05-01

Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma

by Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner, Sabine Merkelbach-Bruse
Published 2019-02-01

ALK G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

by Sebastian Y. F. Michels, Andreas H. Scheel, Thomas Wündisch, Johannes M. Heuckmann, Roopika Menon, Michael Puesken, Carsten Kobe, Helen Pasternack, Carina Heydt, Matthias Scheffler, Rieke Fischer, Anne M. Schultheis, Sabine Merkelbach-Bruse, Lukas Heukamp, Reinhard Büttner, Jürgen Wolf
Published 2017-03-01

Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

by Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2021-02-01

Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis

by Hanibal Bohnenberger, Lars Kaderali, Philipp Ströbel, Diego Yepes, Uwe Plessmann, Neekesh V Dharia, Sha Yao, Carina Heydt, Sabine Merkelbach‐Bruse, Alexander Emmert, Jonatan Hoffmann, Julius Bodemeyer, Kirsten Reuter‐Jessen, Anna‐Maria Lois, Leif Hendrik Dröge, Philipp Baumeister, Christoph Walz, Lorenz Biggemann, Roland Walter, Björn Häupl, Federico Comoglio, Kuan‐Ting Pan, Sebastian Scheich, Christof Lenz, Stefan Küffer, Felix Bremmer, Julia Kitz, Maren Sitte, Tim Beißbarth, Marc Hinterthaner, Martin Sebastian, Joachim Lotz, Hans‐Ulrich Schildhaus, Hendrik Wolff, Bernhard C Danner, Christian Brandts, Reinhard Büttner, Martin Canis, Kimberly Stegmaier, Hubert Serve, Henning Urlaub, Thomas Oellerich
Published 2018-09-01

Overcoming EGFR G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

by Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A. Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L. Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N. Fischer, Matthias Scheffler, Michaela A. Ihle, Vanessa Priesner, Andreas H. Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F. Smit, Sabine Merkelbach-Bruse, H. Christian Reinhardt, Stefan M. Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L. Sos
Published 2018-11-01