In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles.

by Zumira A Carneiro, Pedro I da S Maia, Renata Sesti-Costa, Carla D Lopes, Tatiana A Pereira, Cristiane M Milanezi, Marcelo A Pereira da Silva, Renata F V Lopez, João S Silva, Victor M Deflon
Published 2014-05-01

Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.

by Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari
Published 2020-03-01

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.

by Aline Sardinha-Silva, Flávia C Mendonça-Natividade, Camila F Pinzan, Carla D Lopes, Diego L Costa, Damien Jacot, Fabricio F Fernandes, André L V Zorzetto-Fernandes, Nicholas J Gay, Alan Sher, Dragana Jankovic, Dominique Soldati-Favre, Michael E Grigg, Maria Cristina Roque-Barreira
Published 2019-06-01

In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex

by Drielly A. Paixão, Carla D. Lopes, Zumira A. Carneiro, Luana M. Sousa, Leticia P. de Oliveira, Norberto P. Lopes, Marcos Pivatto, Joana Darc S. Chaves, Mauro V. de Almeida, Javier Ellena, Mariete B. Moreira, Adelino V.G. Netto, Ronaldo J. de Oliveira, Silvana Guilardi, Sérgio de Albuquerque, Wendell Guerra
Published 2019-01-01

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

by Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Published 2018-04-01