Mycolactone induces cell death by SETD1B-dependent degradation of glutathione.

by Birgit Förster, Caroline Demangel, Thorsten Thye
Published 2020-10-01

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.

by Hui Hong, Emmanuelle Coutanceau, Marion Leclerc, Laxmee Caleechurn, Peter F Leadlay, Caroline Demangel
Published 2008-01-01

Mycolactone displays anti-inflammatory effects on the nervous system.

by Caroline Isaac, Annie Mauborgne, Alfonso Grimaldi, Kemy Ade, Michel Pohl, Cristina Limatola, Yves Boucher, Caroline Demangel, Laure Guenin-Macé
Published 2017-11-01

Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

by Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O’Shea, Matthew K. O’Shea, Claudio Mauro
Published 2021-09-01

Recombinant Antibodies against Mycolactone

by Leslie Naranjo, Fortunato Ferrara, Nicolas Blanchard, Caroline Demangel, Sara D’Angelo, M. Frank Erasmus, Andre A. Teixeira, Andrew R.M. Bradbury
Published 2019-06-01

Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ

by Wei Yu, Chloé Lescale, Loelia Babin, Marie Bedora-Faure, Hélène Lenden-Hasse, Ludivine Baron, Caroline Demangel, José Yelamos, Erika Brunet, Ludovic Deriano
Published 2020-10-01

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

by Reid Oldenburg, Reid Oldenburg, Veronique Mayau, Jacques Prandi, Ainhoa Arbues, Catherine Astarie-Dequeker, Christophe Guilhot, Catherine Werts, Nathalie Winter, Nathalie Winter, Caroline Demangel
Published 2018-01-01

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

by Guillaume Tabouret, Catherine Astarie-Dequeker, Caroline Demangel, Wladimir Malaga, Patricia Constant, Aurélie Ray, Nadine Honoré, Nana Fatimath Bello, Esther Perez, Mamadou Daffé, Christophe Guilhot
Published 2010-10-01

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

by Bruno Tello Rubio, Florence Bugault, Blandine Baudon, Bertrand Raynal, Sébastien Brûlé, Jean-David Morel, Sarah Saint-Auret, Nicolas Blanchard, Caroline Demangel, Laure Guenin-Macé
Published 2021-09-01

CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

by Émilie Doz-Deblauwe, Florence Carreras, Ainhoa Arbues, Aude Remot, Mathieu Epardaud, Wladimir Malaga, Véronique Mayau, Jacques Prandi, Catherine Astarie-Dequeker, Christophe Guilhot, Caroline Demangel, Nathalie Winter
Published 2019-12-01

Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease.

by Richard O Phillips, Fred S Sarfo, Jordi Landier, Reid Oldenburg, Michael Frimpong, Mark Wansbrough-Jones, Kabiru Abass, William Thompson, Mark Forson, Arnaud Fontanet, Fatoumata Niang, Caroline Demangel
Published 2014-04-01

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

by Emma Colucci-Guyon, Aline Rifflet, Sarah Saint-Auret, Anaëlle da Costa, Laurent Boucontet, Thomas Laval, Christophe Prehaud, Nicolas Blanchard, Jean-Pierre Levraud, Ivo G Boneca, Caroline Demangel, Laure Guenin-Macé
Published 2020-12-01

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.

by Fred S Sarfo, Fabien Le Chevalier, N'Guetta Aka, Richard O Phillips, Yaw Amoako, Ivo G Boneca, Pascal Lenormand, Mireille Dosso, Mark Wansbrough-Jones, Romain Veyron-Churlet, Laure Guenin-Macé, Caroline Demangel
Published 2011-07-01

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

by Grégoire Chevalier, Eleni Siopi, Laure Guenin-Macé, Maud Pascal, Thomas Laval, Aline Rifflet, Ivo Gomperts Boneca, Caroline Demangel, Benoit Colsch, Alain Pruvost, Emeline Chu-Van, Aurélie Messager, François Leulier, Gabriel Lepousez, Gérard Eberl, Pierre-Marie Lledo
Published 2020-12-01

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

by Laure Guenin-Macé, Jean-David Morel, Jean-Marc Doisne, Angèle Schiavo, Lysiane Boulet, Véronique Mayau, Pedro Goncalves, Sabine Duchatelet, Alain Hovnanian, Vincent Bondet, Darragh Duffy, Marie-Noëlle Ungeheuer, Maïa Delage, Aude Nassif, James P. Di Santo, Caroline Demangel
Published 2020-10-01

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

by Alejandra Urrutia, Darragh Duffy, Vincent Rouilly, Céline Posseme, Raouf Djebali, Gabriel Illanes, Valentina Libri, Benoit Albaud, David Gentien, Barbara Piasecka, Milena Hasan, Magnus Fontes, Lluis Quintana-Murci, Matthew L. Albert, Laurent Abel, Andres Alcover, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Antonio Freitas, Odile Gelpi, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour, Antoine Toubert, Marie-Noëlle Ungeheuer, Lluis Quintana-Murci, Matthew L. Albert
Published 2016-09-01

Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

by Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Spencer L. Shorte, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, the Milieu Intérieur Consortium, Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Trouvier, Marie-Noëlle Ungeheuer, Darragh Duffy, Matthew L. Albert, Lluis Quintana-Murci
Published 2021-04-01

Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

by Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Spencer L. Shorte, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, Brigitte David-Watine, the Milieu Intérieur Consortium, Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Trouvier, Marie-Noëlle Ungeheuer, Darragh Duffy, Matthew L. Albert, Lluis Quintana-Murci
Published 2021-01-01