Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix.

by Nelson Osuagwu, Christian Dölle, Charalampos Tzoulis
Published 2019-01-01

Understanding the Epilepsy in POLG Related Disease

by Omar Hikmat, Tom Eichele, Charalampos Tzoulis, Laurence A. Bindoff
Published 2017-08-01

Real-World Dosing of OnabotulinumtoxinA and IncobotulinumtoxinA for Cervical Dystonia and Blepharospasm: Results from TRUDOSE and TRUDOSE II

by Ruth Kent, Adrian Robertson, Sandra Quiñones Aguilar, Charalampos Tzoulis, John Maltman
Published 2021-07-01

Novel SACS mutations identified by whole exome sequencing in a norwegian family with autosomal recessive spastic ataxia of Charlevoix-Saguenay.

by Charalampos Tzoulis, Stefan Johansson, Bjørn Ivar Haukanes, Helge Boman, Per Morten Knappskog, Laurence A Bindoff
Published 2013-01-01

Differential transcript usage in the Parkinson's disease brain.

by Fiona Dick, Gonzalo S Nido, Guido Werner Alves, Ole-Bjørn Tysnes, Gry Hilde Nilsen, Christian Dölle, Charalampos Tzoulis
Published 2020-11-01

Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson’s Disease

by Aleksander H. Erga, Ingvild Dalen, Anastasia Ushakova, Janete Chung, Charalampos Tzoulis, Charalampos Tzoulis, Ole Bjørn Tysnes, Ole Bjørn Tysnes, Guido Alves, Guido Alves, Guido Alves, Kenn Freddy Pedersen, Kenn Freddy Pedersen, Jodi Maple-Grødem, Jodi Maple-Grødem
Published 2018-02-01

Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci.

by Johannes Jernqvist Gaare, Gonzalo Nido, Christian Dölle, Paweł Sztromwasser, Guido Alves, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Charalampos Tzoulis
Published 2020-01-01

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

by Irene H. Flønes, Gerda Ricken, Sigrid Klotz, Alexandra Lang, Thomas Ströbel, Christian Dölle, Gabor G. Kovacs, Charalampos Tzoulis
Published 2020-04-01

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

by Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis
Published 2021-05-01

Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition

by Gonzalo S. Nido, Fiona Dick, Lilah Toker, Kjell Petersen, Guido Alves, Ole-Bjørn Tysnes, Inge Jonassen, Kristoffer Haugarvoll, Charalampos Tzoulis
Published 2020-04-01

Using urine to diagnose large‐scale mtDNA deletions in adult patients

by Kristin N. Varhaug, Gonzalo S. Nido, Irenaeus deCoo, Pirjo Isohanni, Anu Suomalainen, Charalampos Tzoulis, Per Knappskog, Laurence A. Bindoff
Published 2020-08-01

Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish

by Yasaman Pakdaman, Yasaman Pakdaman, Yasaman Pakdaman, Elsa Denker, Eirik Austad, William H. J. Norton, Hans O. Rolfsnes, Laurence A. Bindoff, Laurence A. Bindoff, Charalampos Tzoulis, Charalampos Tzoulis, Ingvild Aukrust, Ingvild Aukrust, Per M. Knappskog, Per M. Knappskog, Stefan Johansson, Stefan Johansson, Ståle Ellingsen
Published 2021-09-01

Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci

by Johannes Jernqvist Gaare, Gonzalo Nido, Christian Dölle, Paweł Sztromwasser, Guido Alves, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Charalampos Tzoulis, Giuseppe Novelli
Published 2020-01-01

Spastic paraplegia type 7 is associated with multiple mitochondrial DNA deletions.

by Iselin Marie Wedding, Jeanette Koht, Gia Tuong Tran, Doriana Misceo, Kaja Kristine Selmer, Asbjørn Holmgren, Eirik Frengen, Laurence Bindoff, Chantal M E Tallaksen, Charalampos Tzoulis
Published 2014-01-01

Novel SLC19A3 Promoter Deletion and Allelic Silencing in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy.

by Irene Flønes, Paweł Sztromwasser, Kristoffer Haugarvoll, Christian Dölle, Maria Lykouri, Thomas Schwarzlmüller, Inge Jonassen, Hrvoje Miletic, Stefan Johansson, Per M Knappskog, Laurence A Bindoff, Charalampos Tzoulis
Published 2016-01-01

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

by Christian Dölle, Irene Flønes, Gonzalo S. Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K. Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Laurence A. Bindoff, Charalampos Tzoulis
Published 2016-11-01

Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations

by Kristina Xiao Liang, Cecilie Katrin Kristiansen, Sepideh Mostafavi, Guro Helén Vatne, Gina Alien Zantingh, Atefeh Kianian, Charalampos Tzoulis, Lena Elise Høyland, Mathias Ziegler, Roberto Megias Perez, Jessica Furriol, Zhuoyuan Zhang, Novin Balafkan, Yu Hong, Richard Siller, Gareth John Sullivan, Laurence A Bindoff
Published 2020-10-01

LIVE@Home.Path—innovating the clinical pathway for home-dwelling people with dementia and their caregivers: study protocol for a mixed-method, stepped-wedge, randomized controlled...

by Bettina Sandgathe Husebo, Heather Allore, Wilco Achterberg, Renira Corinne Angeles, Clive Ballard, Frøydis Kristine Bruvik, Stein Erik Fæø, Marie Hidle Gedde, Eirin Hillestad, Frode Fadnes Jacobsen, Øyvind Kirkevold, Egil Kjerstad, Reidun Lisbeth Skeide Kjome, Janne Mannseth, Mala Naik, Rui Nouchi, Nathalie Puaschitz, Rune Samdal, Oscar Tranvåg, Charalampos Tzoulis, Ipsit Vihang Vahia, Maarja Vislapuu, Line Iden Berge
Published 2020-06-01