Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes

by Laura T. Haas, Santiago V. Salazar, Levi M. Smith, Helen R. Zhao, Timothy O. Cox, Charlotte S. Herber, Andrew P. Degnan, Anand Balakrishnan, John E. Macor, Charles F. Albright, Stephen M. Strittmatter
Published 2017-07-01

Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.

by Jere E Meredith, Sethu Sankaranarayanan, Valerie Guss, Anthony J Lanzetti, Flora Berisha, Robert J Neely, J Randall Slemmon, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Holly Soares, Michael Ahlijanian, Charles F Albright
Published 2013-01-01

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

by Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijanian
Published 2015-01-01

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

by Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Published 2014-01-01