Treating Imatinib-Resistant Leukemia: The Next Generation Targeted Therapies

by Michael R. Burgess, Charles L. Sawyers
Published 2006-01-01

Challenges in validating candidate therapeutic targets in cancer

by Jeffrey Settleman, Charles L Sawyers, Tony Hunter
Published 2018-02-01

Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia.

by Kevin Leder, Jasmine Foo, Brian Skaggs, Mercedes Gorre, Charles L Sawyers, Franziska Michor
Published 2011-01-01

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

by Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers
Published 2017-10-01

Cabozantinib Resolves Bone Scans in Tumor-Naïve Mice Harboring Skeletal Injuries

by Michael G. Doran, Daniel E. Spratt, John Wongvipat, David Ulmert, Brett S. Carver, Charles L. Sawyers, Michael J. Evans
Published 2014-10-01

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

by Eugine Lee, John Wongvipat, Danielle Choi, Ping Wang, Young Sun Lee, Deyou Zheng, Philip A Watson, Anuradha Gopalan, Charles L Sawyers
Published 2019-01-01

Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

by Kimberly Brown Dahlman, Joel S Parker, Tambudzai Shamu, Haley Hieronymus, Caren Chapinski, Brett Carver, Kenneth Chang, Gregory J Hannon, Charles L Sawyers
Published 2012-01-01

MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.

by Nicola J Clegg, Suzana S Couto, John Wongvipat, Haley Hieronymus, Brett S Carver, Barry S Taylor, Katharine Ellwood-Yen, William L Gerald, Chris Sander, Charles L Sawyers
Published 2011-03-01

Overcoming mutation-based resistance to antiandrogens with rational drug design

by Minna D Balbas, Michael J Evans, David J Hosfield, John Wongvipat, Vivek K Arora, Philip A Watson, Yu Chen, Geoffrey L Greene, Yang Shen, Charles L Sawyers
Published 2013-04-01

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.

by Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen
Published 2016-01-01

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

by Haley Hieronymus, Rajmohan Murali, Amy Tin, Kamlesh Yadav, Wassim Abida, Henrik Moller, Daniel Berney, Howard Scher, Brett Carver, Peter Scardino, Nikolaus Schultz, Barry Taylor, Andrew Vickers, Jack Cuzick, Charles L Sawyers
Published 2018-09-01

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

by Neel Shah, Ping Wang, John Wongvipat, Wouter R Karthaus, Wassim Abida, Joshua Armenia, Shira Rockowitz, Yotam Drier, Bradley E Bernstein, Henry W Long, Matthew L Freedman, Vivek K Arora, Deyou Zheng, Charles L Sawyers
Published 2017-09-01

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

by Supreet Agarwal, Paul G. Hynes, Heather S. Tillman, Ross Lake, Wassim G. Abou-Kheir, Lei Fang, Orla M. Casey, Amir H. Ameri, Philip L. Martin, Juan Juan Yin, Phillip J. Iaquinta, Wouter R. Karthaus, Hans C. Clevers, Charles L. Sawyers, Kathleen Kelly
Published 2015-12-01

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.

by Tim F Cloughesy, Koji Yoshimoto, Phioanh Nghiemphu, Kevin Brown, Julie Dang, Shaojun Zhu, Teli Hsueh, Yinan Chen, Wei Wang, David Youngkin, Linda Liau, Neil Martin, Don Becker, Marvin Bergsneider, Albert Lai, Richard Green, Tom Oglesby, Michael Koleto, Jeff Trent, Steve Horvath, Paul S Mischel, Ingo K Mellinghoff, Charles L Sawyers
Published 2008-01-01

Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated CancerSummary

by Anna L. Means, Tanner J. Freeman, Jing Zhu, Luke G. Woodbury, Paula Marincola-Smith, Chao Wu, Anne R. Meyer, Connie J. Weaver, Chandrasekhar Padmanabhan, Hanbing An, Jinghuan Zi, Bronson C. Wessinger, Rupesh Chaturvedi, Tasia D. Brown, Natasha G. Deane, Robert J. Coffey, Keith T. Wilson, J. Joshua Smith, Charles L. Sawyers, James R. Goldenring, Sergey V. Novitskiy, M. Kay Washington, Chanjuan Shi, R. Daniel Beauchamp
Published 2018-01-01

Patient derived organoids to model rare prostate cancer phenotypes

by Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R. Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J. McNary, Rachele Rosati, Scott T. Tagawa, David M. Nanus, Juan Miguel Mosquera, Charles L. Sawyers, Yu Chen, Giorgio Inghirami, Rema A. Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A. Rubin, Himisha Beltran
Published 2018-06-01

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

by Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff
Published 2006-12-01