Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

by Elizabeth M. Grimsey, Chiara Fais, Robert L. Marshall, Vito Ricci, Maria Laura Ciusa, Jack W. Stone, Alasdair Ivens, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock
Published 2020-06-01

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from <i>Salmonella</i>

by Rachel M. Johnson, Chiara Fais, Mayuriben Parmar, Harish Cheruvara, Robert L. Marshall, Sophie J. Hesketh, Matthew C. Feasey, Paolo Ruggerone, Attilio V. Vargiu, Vincent L. G. Postis, Stephen P. Muench, Vassiliy N. Bavro
Published 2020-06-01

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

by Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis
Published 2020-11-01