Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

by Anita A. Pinar, Alexander Yuferov, Tracey A. Gaspari, Chrishan S. Samuel, Chrishan S. Samuel
Published 2020-08-01

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis

by Chrishan S. Samuel, Timothy D. Hewitson, Timothy D. Hewitson
Published 2017-11-01

Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia

by Padma Murthi, Anita A. Pinar, Evdokia Dimitriadis, Chrishan S. Samuel
Published 2020-02-01

The Use of Live Cell Imaging and Automated Image Analysis to Assist With Determining Optimal Parameters for Angiogenic Assay in vitro

by Brooke M. Huuskes, Ryan J. DeBuque, Peter G. Kerr, Chrishan S. Samuel, Sharon D. Ricardo
Published 2019-04-01

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity

by Caitlin V. Lewis, Antony Vinh, Henry Diep, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper
Published 2019-01-01

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

by Simon G. Royce, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Sharon D. Ricardo, Chrishan S. Samuel
Published 2015-11-01

Transplantation of Human Amnion Epithelial Cells Reduces Hepatic Fibrosis in Immunocompetent CCl-Treated Mice

by Ursula Manuelpillai, Jorge Tchongue, Dinushka Lourensz, Vijesh Vaghjiani, Chrishan S. Samuel, Alison Liu, Elizabeth D. Williams, William Sievert
Published 2010-09-01

Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-mediated Airway Relaxation

by Maggie Lam, Simon G Royce, Chantal Donovan, Maria Jelinic, Laura J Parry, Chrishan S Samuel, Jane Elizabeth Bourke
Published 2016-10-01

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

by Vinojini B. Nair, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed Akhter Hossain, John D. Wade
Published 2015-01-01

Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice

by Yifang Li, Amlan Chakraborty, Brad R.S. Broughton, Dorota Ferens, Robert E. Widdop, Sharon D. Ricardo, Chrishan S. Samuel
Published 2021-12-01

Endothelial Progenitor Cells and Vascular Health in Dialysis Patients

by Brooke M. Huuskes, Ryan J. DeBuque, Kevan R. Polkinghorne, Chrishan S. Samuel, Peter G. Kerr, Sharon D. Ricardo
Published 2018-01-01

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

by Ali Al-Rubaie, Andrea F. Wise, Foula Sozo, Robert De Matteo, Chrishan S. Samuel, Richard Harding, Sharon D. Ricardo
Published 2018-06-01

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?

by Seshini Gurusinghe, Russell D Brown, Xiaochu Cai, Chrishan S Samuel, Sharon D Ricardo, Merlin C Thomas, Michelle M Kett
Published 2013-01-01

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

by Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross A D Bathgate, Tim D Hewitson, Chrishan S Samuel
Published 2012-01-01

THE ANTI-FIBROTIC ACTIONS OF RELAXIN ARE MEDIATED THROUGH A NO-sGC-cGMP-DEPENDENT PATHWAY IN RENAL MYOFIBROBLASTS IN VITRO AND ENHANCED BY THE NO DONOR, DIETHYLAMINE NONOATE

by Chao eWang, Barbara Kathryn Kemp-Harper, Martina eKocan, Sheng Yu eAng, Tim David Hewitson, Chrishan S Samuel
Published 2016-03-01

Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study.

by Yuben Moodley, Vijesh Vaghjiani, James Chan, Svetlana Baltic, Marisa Ryan, Jorge Tchongue, Chrishan S Samuel, Padma Murthi, Ornella Parolini, Ursula Manuelpillai
Published 2013-01-01

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

by Anna C Simcocks, Kayte A Jenkin, Lannie O’Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch, Deanne H Hryciw
Published 2019-02-01

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

by Timothy D. Hewitson, Timothy D. Hewitson, Stephen G. Holt, Stephen G. Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S. Samuel, Edward R. Smith, Edward R. Smith
Published 2017-05-01

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

by Nadia Mazarakis, Jitraporn Vongsvivut, Keith R. Bambery, Katherine Ververis, Mark J. Tobin, Simon G. Royce, Chrishan S. Samuel, Kenneth J. Snibson, Paul V. Licciardi, Tom C. Karagiannis
Published 2020-07-01

Anti-fibrotic Potential of AT2 Receptor Agonists

by Yan Wang, Mark Del Borgo, Huey W. Lee, Dhaniel Baraldi, Baydaa Hirmiz, Tracey A. Gaspari, Kate M. Denton, Marie-Isabel Aguilar, Chrishan S. Samuel, Robert E. Widdop
Published 2017-08-01