SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations

by Linda Pudelko, Frank Jaehrling, Christof Reusch, Santiago Viteri, Christopher Stroh, Nina Linde, Michael P. Sanderson, Doreen Musch, Catherine Jorand Lebrun, Marina Keil, Christina Esdar, Andree Blaukat, Rafael Rosell, Karl Maria Schumacher, Niki Karachaliou
Published 2020-12-01

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.

by Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Mairian Thomas, Jennifer R Shone, Delyth A Badder, Marc Naven, Kevin E Ashelford, Rachel Hargest, Alan R Clarke, Christina Esdar, Hans-Peter Buchstaller, J Mark Treherne, Sylvia Boj, Bahar Ramezanpour, Dirk Wienke, Leo S Price, Paul H Shaw, Trevor C Dale
Published 2020-01-01

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

by Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Ken Ewan, Sharon Gowan, Alexis De Haven Brandon, Phillip Hewitt, Stephen M Hobbs, Wolfgang Kaufmann, Aurélie Mallinger, Florence Raynaud, Toby Roe, Felix Rohdich, Kai Schiemann, Stephanie Simon, Richard Schneider, Melanie Valenti, Stefan Weigt, Julian Blagg, Andree Blaukat, Trevor C Dale, Suzanne A Eccles, Stefan Hecht, Klaus Urbahns, Paul Workman, Dirk Wienke
Published 2016-12-01