TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

by Georgia Deliyannis, Chinn Yi Wong, Hayley A. McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E. Scott, Sarah L. Londrigan, Patrick C. Reading, Nathan W. Bartlett, Katherine Kedzierska, Lorena E. Brown, Francesca Mercuri, Christophe Demaison, David C. Jackson, Brendon Y. Chua
Published 2021-03-01

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

by Pamela C. Proud, Daphne Tsitoura, Robert J. Watson, Brendon Y. Chua, Marilyn J. Aram, Kevin R. Bewley, Breeze E. Cavell, Rebecca Cobb, Stuart Dowall, Susan A. Fotheringham, Catherine M.K. Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A. Ryan, Gillian S. Slack, Stephen Thomas, Nadina I. Wand, Paul Yeates, Christophe Demaison, Weiguang Zeng, Ian Holmes, David C. Jackson, Nathan W. Bartlett, Francesca Mercuri, Miles W. Carroll
Published 2021-01-01