Destination Airway: Tracking Granulocytes in Asthma

by Christopher E. Brightling
Published 2014-12-01

Proning reduces ventilation heterogeneity in patients with elevated BMI: implications for COVID-19 pneumonia management?

by Brody H. Foy, Christopher E. Brightling, Salman Siddiqui
Published 2020-07-01

Interleukin‐18, IL‐18 binding protein and IL‐18 receptor expression in asthma: a hypothesis showing IL‐18 promotes epithelial cell differentiation

by Davinder Kaur, Latifa Chachi, Edith Gomez, Nicolas Sylvius, Christopher E Brightling
Published 2021-01-01

Neutrophil elastase as a biomarker for bacterial infection in COPD

by Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro, Mona Bafadhel
Published 2019-07-01

The stability of blood Eosinophils in chronic obstructive pulmonary disease

by Gabriella H. Long, Thomas Southworth, Umme Kolsum, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh
Published 2020-01-01

A systematic review of the diagnostic accuracy of volatile organic compounds in airway diseases and their relation to markers of type-2 inflammation

by Wadah Ibrahim, Sushiladevi Natarajan, Michael Wilde, Rebecca Cordell, Paul S. Monks, Neil Greening, Christopher E. Brightling, Rachael Evans, Salman Siddiqui
Published 2021-08-01

COPD in the time of COVID-19: an analysis of acute exacerbations and reported behavioural changes in patients with COPD

by Hamish McAuley, Kate Hadley, Omer Elneima, Christopher E. Brightling, Rachael A. Evans, Michael C. Steiner, Neil J. Greening
Published 2021-01-01

Development and Analysis of Patient-Based Complete Conducting Airways Models.

by Rafel Bordas, Christophe Lefevre, Bart Veeckmans, Joe Pitt-Francis, Catalin Fetita, Christopher E Brightling, David Kay, Salman Siddiqui, Kelly S Burrowes
Published 2015-01-01

Bacteria and sputum inflammatory cell counts; a COPD cohort analysis

by Augusta S. Beech, Simon Lea, Umme Kolsum, Zhang Wang, Bruce E. Miller, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh
Published 2020-11-01

Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.

by Neil Martin, Andrew Ruddick, Greer K Arthur, Heidi Wan, Lucy Woodman, Christopher E Brightling, Don J L Jones, Ian D Pavord, Peter Bradding
Published 2012-01-01

An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma.

by Gautam Damera, Kirk M Druey, Philip R Cooper, Vera P Krymskaya, Roy J Soberman, Yassine Amrani, Toshinori Hoshi, Christopher E Brightling, Reynold A Panettieri
Published 2012-01-01

A Refined View of Airway Microbiome in Chronic Obstructive Pulmonary Disease at Species and Strain-Levels

by Zhang Wang, Haiyue Liu, Fengyan Wang, Yuqiong Yang, Xiaojuan Wang, Boxuan Chen, Martin R. Stampfli, Hongwei Zhou, Wensheng Shu, Christopher E. Brightling, Zhenyu Liang, Rongchang Chen, Rongchang Chen
Published 2020-07-01

Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics.

by Koirobi Haldar, Mona Bafadhel, Kelvin Lau, Adam Berg, Brenda Kwambana, Tatiana Kebadze, Mohammadali Yavari Ramsheh, Bethan Barker, Pranabashis Haldar, Sebastian Johnston, Julian M Ketley, Christopher E Brightling, Michael R Barer
Published 2017-01-01

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

by Wadah Ibrahim, Rebecca L. Cordell, Michael J. Wilde, Matthew Richardson, Liesl Carr, Ananga Sundari Devi Dasi, Beverley Hargadon, Robert C. Free, Paul S. Monks, Christopher E. Brightling, Neil J. Greening, Salman Siddiqui
Published 2021-07-01

Blood and sputum eosinophils in COPD; relationship with bacterial load

by Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh
Published 2017-05-01

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

by Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger
Published 2021-08-01

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

by Martin A Bewley, Kylie B R Belchamber, Kirandeep K Chana, Richard C Budd, Gavin Donaldson, Jadwiga A Wedzicha, Christopher E Brightling, Iain Kilty, Louise E Donnelly, Peter J Barnes, Dave Singh, Moira K B Whyte, David H Dockrell, COPDMAP
Published 2016-01-01

The sputum microbiome is distinct between COPD and health, independent of smoking history

by Koirobi Haldar, Leena George, Zhang Wang, Vijay Mistry, Mohammadali Yavari Ramsheh, Robert C. Free, Catherine John, Nicola F. Reeve, Bruce E. Miller, Ruth Tal-Singer, Adam J. Webb, Anthony J. Brookes, Martin D. Tobin, Dave Singh, Gavin C. Donaldson, Jadwiga A. Wedzicha, James R. Brown, Michael R. Barer, Christopher E. Brightling
Published 2020-07-01

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protoco...

by Catherine E. Hanratty, John G. Matthews, Joseph R. Arron, David F. Choy, Ian D. Pavord, P. Bradding, Christopher E. Brightling, Rekha Chaudhuri, Douglas C. Cowan, Ratko Djukanovic, Nicola Gallagher, Stephen J. Fowler, Tim C. Hardman, Tim Harrison, Cécile T. Holweg, Peter H. Howarth, James Lordan, Adel H. Mansur, Andrew Menzies-Gow, Sofia Mosesova, Robert M. Niven, Douglas S. Robinson, Dominick E. Shaw, Samantha Walker, Ashley Woodcock, Liam G. Heaney, on behalf of the RASP-UK (Refractory Asthma Stratification Programme) Consortium
Published 2018-01-01

Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

by Marion Engel, David Endesfelder, Brigitte Schloter-Hai, Susanne Kublik, Michael S Granitsiotis, Piera Boschetto, Mariarita Stendardo, Imre Barta, Balazs Dome, Jean-François Deleuze, Anne Boland, Joachim Müller-Quernheim, Antje Prasse, Tobias Welte, Jens Hohlfeld, Deepak Subramanian, David Parr, Ivo Glynne Gut, Timm Greulich, Andreas Rembert Koczulla, Adam Nowinski, Dorota Gorecka, Dave Singh, Sumit Gupta, Christopher E Brightling, Harald Hoffmann, Marion Frankenberger, Thomas P Hofer, Dorothe Burggraf, Marion Heiss-Neumann, Loems Ziegler-Heitbrock, Michael Schloter, Wolfgang Zu Castell
Published 2017-01-01