Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

by Cirit, Murat
Published 2018

Maximizing the Impact of Microphysiological Systems with in Vitro-in Vivo Translation

by Stokes, Cynthia L., Cirit, Murat
Published 2018

Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems

by Stokes, CL, Lauffenburger, Douglas A, Cirit, Murat
Published 2017

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

by Stokes, Cynthia L., Maass, Christian Alexander, Griffith, Linda G, Cirit, Murat
Published 2018

Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics

by Wang, Xin, Cirit, Murat, Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven R
Published 2020

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

by Kostrzewski, T., Stokes, C. L., Hughes, D. J., Tsamandouras, Nikolaos, Griffith, Linda G, Cirit, Murat
Published 2018

Translational Assessment of Drug‐Induced Proximal Tubule Injury Using a Kidney Microphysiological System

by Maass, Christian, Sorensen, Nathan B, Himmelfarb, Jonathan, Kelly, Edward J, Stokes, Cynthia L, Cirit, Murat
Published 2022

Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling

by Mina, Sara G., Alaybeyoglu, Begum, Murphy, William L., Thomson, James A., Stokes, Cynthia L., Cirit, Murat
Published 2020

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

by Stokes, Cynthia L, Tsamandouras, Nikolaos, Chen, Wen Li, Edington, Collin D, Griffith, Linda G, Cirit, Murat
Published 2017

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

by Stokes, Cynthia L, Tsamandouras, Nikolaos, Chen, Wen Li, Edington, Collin D, Griffith, Linda G, Cirit, Murat
Published 2017

Integration of systems biology with organs-on-chips to humanize therapeutic development

by Clark, Amanda M., Wells, Alan, Edington, Collin D, Cirit, Murat, Chen, Wen Li, Trumper, David L, Griffith, Linda G
Published 2018

Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

by Dwivedi, Garima, Flaman, Lisa, Alaybeyoglu, Begum, Struglics, André, Frank, Eliot H., Chubinskya, Susan, Trippel, Stephen B., Rosen, Vicki, Cirit, Murat, Grodzinsky, Alan J.
Published 2022

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies

by Dallas, Matthew, Stokes, Cynthia L., Maass, Christian Alexander, LaBarge, Matthew E, Shockley, Michael J, Valdez Macias, Jorge Luis, Geishecker, Emily R, Griffith, Linda G, Cirit, Murat
Published 2018

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration

by Large, E. M., Hughes, D. J., Stokes, C. L., Yu, Jiajie, Cilfone, Nicholas A., Sarkar, Ujjal, Tannenbaum, Steven R, Lauffenburger, Douglas A, Griffith, Linda G, Cirit, Murat, Wishnok, John S.
Published 2017

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R
Published 2017

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk

by Large, Emma M., Venkataramanan, Raman, Hughes, David J., Stokes, Cynthia L., Chen, Wen Li, Edington, Collin D, Suter, Emily C, Yu, Jiajie, Velazquez, Jeremy J., Velazquez, Jason G, Shockley, Michael J, Trumper, David L, Carrier, Rebecca, Cirit, Murat, Griffith, Linda G, Lauffenburger, Douglas A
Published 2018

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

by Edington, Collin D, Chen, Wen Li, Geishecker, Emily R, Kassis, Timothy, Soenksen Martinez, Luis Ruben, Bhushan, Brij M, Maass, Christian Alexander, Tsamandouras, Nikolaos, Valdez Macias, Jorge Luis, Cook, Christi Dionne, Yu, Jiajie, Suter, Emily C, Shockley, Michael J, Velazquez, Jason G, Velazquez, Jeremy J., Stockdale, Linda, Papps, Julia P, Lee, Iris, Vann, Nicholas W., Contreras Gamboa, Mario e, LaBarge, Matthew E, Zhong, Zhe, Wang, Xin, Boyer, Laurie Ann, Lauffenburger, Douglas A, Carrier, Rebecca, Communal, Catherine, Tannenbaum, Steven R, Trumper, David L, Cirit, Murat, Griffith, Linda G
Published 2018