Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish...

by Claudia Tulotta, Cristina Stefanescu, Elena Beletkaia, Jeroen Bussmann, Katsiaryna Tarbashevich, Thomas Schmidt, B. Ewa Snaar-Jagalska
Published 2016-02-01

Differential effects of zoledronic acid and oestrogen on anti-cancer immunity

by Chris George, Diane Lefley, Victor Canuas-Landero, Claudia Tulotta, Hannah Corness, Caroline Wilson, Munitta Muthana, Penelope Ottewell
Published 2021-04-01

The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma

by Philipp Berning, Carolin Hennemann, Claudia Tulotta, Christiane Schaefer, Birgit Lechtape, Marc Hotfilder, Yassmine El Gourari, Heribert Jürgens, Ewa Snaar-Jagalska, Georg Hempel, Uta Dirksen, Jenny Potratz
Published 2020-04-01

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

by Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Published 2019-11-01

IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer

by Claudia Tulotta, Diane V. Lefley, Charlotte K. Moore, Ana E. Amariutei, Amy R. Spicer-Hadlington, Lewis A. Quayle, Russell O. Hughes, Khawla Ahmed, Victoria Cookson, Catherine A. Evans, Jayakumar Vadakekolathu, Paul Heath, Sheila Francis, Emmanuel Pinteaux, A. Graham Pockley, Penelope D. Ottewell
Published 2021-07-01

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

by Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Published 2019-11-01

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

by Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince
Published 2019-10-01