Targeted Molecular Therapy in Glioblastoma

by Claudio Festuccia, Assunta Leda Biordi, Vincenzo Tombolini, Akira Hara, David Bailey
Published 2020-01-01

Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

by Eulalio Gracia, Andrea Mancini, Alessandro Colapietro, Cristina Mateo, Ignacio Gracia, Claudio Festuccia, Manuel Carmona
Published 2019-09-01

The Importance of Tumor Stem Cells in Glioblastoma Resistance to Therapy

by Vincenzo Mattei, Francesca Santilli, Stefano Martellucci, Simona Delle Monache, Jessica Fabrizi, Alessandro Colapietro, Adriano Angelucci, Claudio Festuccia
Published 2021-04-01

Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps?

by Antonella Vetuschi, Simona Pompili, Gian Piero Di Marco, Federico Calvaruso, Enzo Iacomino, Lidia Angelosante, Claudio Festuccia, Alessandro Colapietro, Roberta Sferra
Published 2020-01-01

The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistoch...

by Roberta Sferra, Simona Pompili, Claudio Festuccia, Francesco Marampon, Giovanni L. Gravina, Luca Ventura, Ernesto Di Cesare, Sara Cicchinelli, Eugenio Gaudio, Antonella Vetuschi
Published 2017-05-01

Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma

by Alessandro Colapietro, Andrea Mancini, Flora Vitale, Stefano Martellucci, Adriano Angelucci, Silvia Llorens, Vincenzo Mattei, Giovanni Luca Gravina, Gonzalo Luis Alonso, Claudio Festuccia
Published 2020-01-01

In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth: Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells

by Alessandra Colciago, Massimiliano Ruscica, Ornella Mornati, Margherita Piccolella, Marina Montagnani-Marelli, Ivano Eberini, Claudio Festuccia, Paolo Magni, Marcella Motta, Paola Negri-Cesi
Published 2014-01-01

The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

by Giovanni Luca Gravina, Andrea Mancini, Francesco Marampon, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Peter J. Richardson, Lee Patient, Stephen Burbidge, Claudio Festuccia
Published 2017-01-01

Dual PI3 K/mTOR inhibition reduces prostate cancer bone engraftment altering tumor-induced bone remodeling

by Andrea Mancini, Alessandro Colapietro, Simona Pompili, Andrea Del Fattore, Simona Delle Monache, Leda Assunta Biordi, Adriano Angelucci, Vincenzo Mattei, Chris Liang, Giovanni Luca Gravina, Claudio Festuccia
Published 2018-04-01

The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine...

by Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Simona Pompili, Flora Vitale, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, Leda Biordi, David Sherris, Claudio Festuccia
Published 2019-10-01

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma

by Claudio Festuccia, Andrea Mancini, Alessandro Colapietro, Giovanni Luca Gravina, Flora Vitale, Francesco Marampon, Simona Delle Monache, Simona Pompili, Loredana Cristiano, Antonella Vetuschi, Vincenzo Tombolini, Yi Chen, Thomas Mehrling
Published 2018-02-01

The novel CXCR4 antagonist, PRX177561, reduces tumor cell proliferation and accelerates cancer stem cell differentiation in glioblastoma preclinical models

by Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Flora Vitale, Antonella Vetuschi, Simona Pompili, Giulia Rossi, Francesco Marampon, Peter J Richardson, Lee Patient, Lee Patient, Stephen Burbidge, Claudio Festuccia
Published 2017-06-01

Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models

by Claudio Festuccia, Andrea Mancini, Giovanni Luca Gravina, Luca Scarsella, Silvia Llorens, Gonzalo L. Alonso, Carla Tatone, Ernesto Di Cesare, Emmanuele A. Jannini, Andrea Lenzi, Anna M. D’Alessandro, Manuel Carmona
Published 2014-01-01

Erratum to “Strategies for Imaging Androgen Receptor Signaling Pathway in Prostate Cancer: Implications for Hormonal Manipulation and Radiation Treatment”

by Giovanni L. Gravina, Claudio Festuccia, Pierluigi Bonfili, Mario Di Staso, Pietro Franzese, Valeria Ruggieri, Vladimir M. Popov, Vincenzo Tombolini, Carlo Masciocchi, Eleonora Carosa, Andrea Lenzi, Emmanuele A. Jannini, Ernesto Di Cesare
Published 2014-01-01

Strategies for Imaging Androgen Receptor Signaling Pathway in Prostate Cancer: Implications for Hormonal Manipulation and Radiation Treatment

by Gravina Giovanni Luca, Claudio Festuccia, Pierluigi Bonfili, Mario Di Staso, Pietro Franzese, Valeria Ruggieri, Vladimir M. Popov, Vincenzo Tombolini, Carlo Masciocchi, Eleonora Carosa, Andrea Lenzi, Emmanuele A. Jannini, Ernesto Di Cesare
Published 2013-01-01

The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models

by Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Loredana Cristiano, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Giocondo Lorenzon, Ellen van der Aar, Claudio Festuccia
Published 2019-03-01

The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Pro...

by Alessandro Colapietro, Peiying Yang, Alessandra Rossetti, Andrea Mancini, Flora Vitale, Stefano Martellucci, Stefano Martellucci, Tara L. Conway, Sharmistha Chakraborty, Francesco Marampon, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Assunta Leda Biordi, Daoyan Wei, Robert A. Newman, Claudio Festuccia
Published 2020-09-01

Antitumorigenic Effects of Inhibiting Ephrin Receptor Kinase Signaling by GLPG1790 against Colorectal Cancer Cell Lines In Vitro and In Vivo

by Alessandro Colapietro, Giovanni Luca Gravina, Francesco Petragnano, Irene Fasciani, Bianca Maria Scicchitano, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Daniela Musio, Francesca De Felice, Vincenzo Mattei, Stefano Martellucci, Roberto Maggio, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
Published 2020-01-01

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embr...

by Francesca Megiorni, Giovanni Luca Gravina, Simona Camero, Simona Ceccarelli, Andrea Del Fattore, Vincenzo Desiderio, Federica Papaccio, Heather P. McDowell, Rajeev Shukla, Antonio Pizzuti, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Roberto Maggio, Francesca De Felice, Cinzia Marchese, Carlo Dominici, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
Published 2017-10-01

Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization

by Francesco Petragnano, Ilaria Pietrantoni, Simona Camero, Silvia Codenotti, Luisa Milazzo, Francesca Vulcano, Giampiero Macioce, Ilenia Giordani, Paolo Tini, Sara Cheleschi, Giovanni Luca Gravina, Claudio Festuccia, Alessandra Rossetti, Simona Delle Monache, Alessandra Ordinelli, Carmela Ciccarelli, Annunziata Mauro, Barboni Barbara, Cristina Antinozzi, Amalia Schiavetti, Roberto Maggio, Luigi Di Luigi, Antonella Polimeni, Cinzia Marchese, Vincenzo Tombolini, Alessandro Fanzani, Nicola Bernabò, Francesca Megiorni, Francesco Marampon
Published 2020-08-01