Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy

by Cody D. Moorman, Sue J. Sohn, Hyewon Phee
Published 2021-03-01

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro

by Kayla B. DeOca, Cody D. Moorman, Brandon L. Garcia, Mark D. Mannie
Published 2020-09-01

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experim...

by Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie
Published 2020-06-01

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy

by Daniel S. Wilkinson, Debjani Ghosh, Rebecca A. Nickle, Cody D. Moorman, Mark D. Mannie
Published 2017-12-01

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Effici...

by Cody D. Moorman, Alan D. Curtis, Alexander G. Bastian, Sarah E. Elliott, Mark D. Mannie
Published 2019-01-01