Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel

by Bethan A. Cole, Rachel M. Johnson, Hattapark Dejakaisaya, Nadia Pilati, Colin W.G. Fishwick, Stephen P. Muench, Jonathan D. Lippiat
Published 2020-05-01

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

by Antony M Latham, Jayakanth Kankanala, Gareth W Fearnley, Matthew C Gage, Mark T Kearney, Shervanthi Homer-Vanniasinkam, Stephen B Wheatcroft, Colin W G Fishwick, Sreenivasan Ponnambalam
Published 2014-01-01

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery

by Kangsa Amporndanai, Rachel M. Johnson, Paul M. O'Neill, Colin W. G. Fishwick, Alexander H. Jamson, Shaun Rawson, Stephen P. Muench, S. Samar Hasnain, Svetlana V. Antonyuk
Published 2018-03-01

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

by Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield
Published 2016-08-01

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from<em> Escherichia coli</em>

by Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem
Published 2020-06-01

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

by Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd, Stanislav Gobec, Dean Rea, Vilmos Fülöp, Christopher W. Thoroughgood, Katie J. Simmons, Christopher G. Dowson, Colin W. G. Fishwick, Luiz Pedro S. de Carvalho, David I. Roper
Published 2017-12-01

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

by Joseph D. Lykins, Ekaterina V. Filippova, Andrei S. Halavaty, George Minasov, Ying Zhou, Ievgeniia Dubrovska, Kristin J. Flores, Ludmilla A. Shuvalova, Jiapeng Ruan, Kamal El Bissati, Sarah Dovgin, Craig W. Roberts, Stuart Woods, Jon D. Moulton, Hong Moulton, Martin J. McPhillie, Stephen P. Muench, Colin W. G. Fishwick, Elisabetta Sabini, Dhanasekaran Shanmugam, David S. Roos, Rima McLeod, Rima McLeod, Wayne F. Anderson, Huân M. Ngô, Huân M. Ngô
Published 2018-10-01

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

by Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod, Rima McLeod
Published 2020-06-01