Optimization of trans-Splicing for Huntington's Disease RNA Therapy

by Hansjörg Rindt, Colton M. Tom, Christian L. Lorson, Virginia B. Mattis
Published 2017-10-01

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation

by Shagun R. Mehta, Colton M. Tom, Yizhou Wang, Catherine Bresee, David Rushton, Pranav P. Mathkar, Jie Tang, Virginia B. Mattis
Published 2018-10-01

Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

by Veronica J. Garcia, David J. Rushton, David J. Rushton, Colton M. Tom, Nicholas D. Allen, Paul J. Kemp, Clive N. Svendsen, Virginia B. Mattis
Published 2019-06-01

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

by Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell, Amber L. Southwell
Published 2020-09-01