Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo

by Jon J. Vermeire, Brian M. Suzuki, Conor R. Caffrey
Published 2016-07-01

Cure of hookworm infection with a cysteine protease inhibitor.

by Jon J Vermeire, Lorine D Lantz, Conor R Caffrey
Published 2012-01-01

Anthelmintics: From discovery to resistance II (San Diego, 2016)

by Richard J. Martin, Adrian J. Wolstenholme, Conor R. Caffrey
Published 2016-12-01

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

by Jan Glaser, Uta Schurigt, Brian M. Suzuki, Conor R. Caffrey, Ulrike Holzgrabe
Published 2015-06-01

Cysteine proteases as digestive enzymes in parasitic helminths.

by Conor R Caffrey, Louise Goupil, Karina M Rebello, John P Dalton, David Smith
Published 2018-08-01

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs.

by Maha-Hamadien Abdulla, Kee-Chong Lim, James H McKerrow, Conor R Caffrey
Published 2011-10-01

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development

by Nelly El-Sakkary, Steven Chen, Michelle R. Arkin, Conor R. Caffrey, Paula Ribeiro
Published 2018-07-01

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib

by Svenja Beckmann, Thavy Long, Christina Scheld, Rudolf Geyer, Conor R. Caffrey, Christoph G. Grevelding
Published 2014-12-01

Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni

by Gertrude Kyere-Davies, Christian Agyare, Yaw Duah Boakye, Brian M. Suzuki, Conor R. Caffrey
Published 2018-01-01

A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.

by Kateryna Soloviova, Ellen C Fox, John P Dalton, Conor R Caffrey, Stephen J Davies
Published 2019-01-01

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

by Susan T Mashiyama, Kyriacos Koupparis, Conor R Caffrey, James H McKerrow, Patricia C Babbitt
Published 2012-01-01

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

by Steven Chen, Brian M. Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R. Arkin, Conor R. Caffrey
Published 2020-12-01

Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.

by Maha-Hamadien Abdulla, Kee-Chong Lim, Mohammed Sajid, James H McKerrow, Conor R Caffrey
Published 2007-01-01

Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.

by Liliana Rojo-Arreola, Thavy Long, Dan Asarnow, Brian M Suzuki, Rahul Singh, Conor R Caffrey
Published 2014-01-01

Cysteine proteases during larval migration and development of helminths in their final host.

by Alexandra Grote, Conor R Caffrey, Karina M Rebello, David Smith, John P Dalton, Sara Lustigman
Published 2018-08-01

Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics.

by Laura Abriola, Denton Hoyer, Conor R Caffrey, David L Williams, Timothy P Yoshino, Jon J Vermeire
Published 2019-01-01

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni.

by Conor R Caffrey, Andreas Rohwer, Frank Oellien, Richard J Marhöfer, Simon Braschi, Guilherme Oliveira, James H McKerrow, Paul M Selzer
Published 2009-01-01

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystati...

by Hana Dvořáková, Roman Leontovyč, Tomáš Macháček, Anthony J. O'Donoghue, Ondřej Šedo, Zbyněk Zdráhal, Charles S. Craik, Conor R. Caffrey, Petr Horák, Libor Mikeš
Published 2020-02-01

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni

by Alexandra Probst, Thi N. Nguyen, Nelly El-Sakkary, Danielle Skinner, Brian M. Suzuki, Frederick S. Buckner, Michael H. Gelb, Conor R. Caffrey, Anjan Debnath
Published 2019-05-01

Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil.

by Alda Maria Soares Silveira, Emanuele Gama Dutra Costa, Debalina Ray, Brian M Suzuki, Michael H Hsieh, Lucia Alves de Oliveira Fraga, Conor R Caffrey
Published 2016-01-01