Distinct pools of non-glycolytic substrates differentiate brain regions and prime region-specific responses of mitochondria.

by Do Yup Lee, Zhiyin Xun, Virginia Platt, Helen Budworth, Christie A Canaria, Cynthia T McMurray
Published 2013-01-01

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

by Aris A Polyzos, Nigel I Wood, Paul Williams, Peter Wipf, A Jennifer Morton, Cynthia T McMurray
Published 2018-01-01

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

by Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu
Published 2016-08-01

An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

by Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A. Polyzos, Andrew D. Chen, Michael C. Martin, Edward S. Barnard, James B. Brown, Cynthia T. McMurray
Published 2021-08-01

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.

by Helen Budworth, Faye R Harris, Paul Williams, Do Yup Lee, Amy Holt, Jens Pahnke, Bartosz Szczesny, Karina Acevedo-Torres, Sylvette Ayala-Peña, Cynthia T McMurray
Published 2015-08-01

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

by Zhiyin Xun, Sulay Rivera-Sánchez, Sylvette Ayala-Peña, James Lim, Helen Budworth, Erin M. Skoda, Paul D. Robbins, Laura J. Niedernhofer, Peter Wipf, Cynthia T. McMurray
Published 2012-11-01