Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma

by Alvaro Gonzalez-Rajal, Jordan F. Hastings, D. Neil Watkins, D. Neil Watkins, David R. Croucher, David R. Croucher, Andrew Burgess, Andrew Burgess
Published 2020-05-01

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

by Catherine R. Cochrane, Anette Szczepny, D. Neil Watkins, Jason E. Cain
Published 2015-08-01

Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo.

by Bassem Akladios, Veronica Mendoza Reinoso, Jason E Cain, Taopeng Wang, Duncan L Lambie, D Neil Watkins, Annemiek Beverdam
Published 2017-01-01

Ancient origin of the new developmental superfamily DANGER.

by Nikolas Nikolaidis, Dimitra Chalkia, D Neil Watkins, Roxanne K Barrow, Solomon H Snyder, Damian B van Rossum, Randen L Patterson
Published 2007-02-01

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma

by Christine L. White, W. Samantha N. Jayasekara, Daniel Picard, Jasmine Chen, D. Neil Watkins, Jason E. Cain, Marc Remke, Daniel J. Gough
Published 2019-11-01

Chiral DNA sequences as commutable controls for clinical genomics

by Ira W. Deveson, Bindu Swapna Madala, James Blackburn, Chris Barker, Ted Wong, Kirston M. Barton, Martin A. Smith, D. Neil Watkins, Tim R. Mercer
Published 2019-03-01

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.

by Kevin Pruitt, Rebekah L Zinn, Joyce E Ohm, Kelly M McGarvey, Sung-Hae L Kang, D Neil Watkins, James G Herman, Stephen B Baylin
Published 2006-03-01

Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.

by Chuan Bian Lim, Cecilia M Prêle, Hui Min Cheah, Yuen Yee Cheng, Sonja Klebe, Glen Reid, D Neil Watkins, Svetlana Baltic, Philip J Thompson, Steven E Mutsaers
Published 2013-01-01

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells

by Samuel Rogers, Rachael A. McCloy, Benjamin L. Parker, Rima Chaudhuri, Velimir Gayevskiy, Nolan J. Hoffman, D. Neil Watkins, Roger J. Daly, David E. James, Andrew Burgess
Published 2015-12-01

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

by Tara L Lin, Qiuju H Wang, Patrick Brown, Craig Peacock, Akil A Merchant, Sarah Brennan, Evan Jones, Karen McGovern, D Neil Watkins, Kathleen M Sakamoto, William Matsui
Published 2010-12-01

Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury

by Elizabeth Verghese, Luciano G. Martelotto, Jason E. Cain, Timothy M. Williams, Andrea F. Wise, Prudence A. Hill, Robyn G. Langham, D. Neil Watkins, Sharon D. Ricardo, James A. Deane
Published 2019-11-01

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells

by Jason E. Cain, Andrew McCaw, W. Samantha N. Jayasekara, Fernando J. Rossello, Kieren D. Marini, Aaron T. Irving, Maya Kansara, David M. Thomas, David M. Ashley, D. Neil Watkins
Published 2013-01-01

Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines.

by Yvonne G van der Zwan, Martin A Rijlaarsdam, Fernando J Rossello, Amanda J Notini, Suzan de Boer, D Neil Watkins, Ad J M Gillis, Lambert C J Dorssers, Stefan J White, Leendert H J Looijenga
Published 2014-01-01

Next-generation sequence analysis of cancer xenograft models.

by Fernando J Rossello, Richard W Tothill, Kara Britt, Kieren D Marini, Jeanette Falzon, David M Thomas, Craig D Peacock, Luigi Marchionni, Jason Li, Samara Bennett, Erwin Tantoso, Tracey Brown, Philip Chan, Luciano G Martelotto, D Neil Watkins
Published 2013-01-01

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

by Jordan F Hastings, Alvaro Gonzalez Rajal, Sharissa L Latham, Jeremy ZR Han, Rachael A McCloy, Yolande EI O'Donnell, Monica Phimmachanh, Alexander D Murphy, Adnan Nagrial, Dariush Daneshvar, Venessa Chin, D Neil Watkins, Andrew Burgess, David R Croucher
Published 2020-06-01

A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

by Alvaro Gonzalez Rajal, Kamila A Marzec, Rachael A McCloy, Max Nobis, Venessa Chin, Jordan F Hastings, Kaitao Lai, Marina Kennerson, William E Hughes, Vijesh Vaghjiani, Paul Timpson, Jason E Cain, D Neil Watkins, David R Croucher, Andrew Burgess
Published 2021-05-01

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

by Chae Ho Lim, Qi Sun, Karan Ratti, Soung-Hoon Lee, Ying Zheng, Makoto Takeo, Wendy Lee, Piul Rabbani, Maksim V. Plikus, Jason E. Cain, David H. Wang, D. Neil Watkins, Sarah Millar, M. Mark Taketo, Peggy Myung, George Cotsarelis, Mayumi Ito
Published 2018-11-01

Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens.

by Tracy L Leong, Kieren D Marini, Fernando J Rossello, Samantha N Jayasekara, Prudence A Russell, Zdenka Prodanovic, Beena Kumar, Vinod Ganju, Muhammad Alamgeer, Louis B Irving, Daniel P Steinfort, Craig D Peacock, Jason E Cain, Anette Szczepny, D Neil Watkins
Published 2014-01-01

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.

by Candice Alexandra Grzelak, Nicholas David Sigglekow, Janina Elke Eleonore Tirnitz-Parker, Elizabeth Jane Hamson, Alessandra Warren, Bharvi Maneck, Jinbiao Chen, Bramilla Patkunanathan, Jade Boland, Robert Cheng, Nicholas Adam Shackel, Devanshi Seth, David Geoffrey Bowen, Luciano Gastón Martelotto, D Neil Watkins, Geoffrey William McCaughan
Published 2017-01-01

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

by Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Published 2019-04-01