Multi Locus View: an extensible web-based tool for the analysis of genomic data.

by Martin J. Sergeant, Jim R. Hughes, Lance Hentges, Gerton Lunter, Damien J. Downes, Stephen Taylor
Published 2021-05-01

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

by Yavor K. Bozhilov, Damien J. Downes, Jelena Telenius, A. Marieke Oudelaar, Emmanuel N. Olivier, Joanne C. Mountford, Jim R. Hughes, Richard J. Gibbons, Douglas R. Higgs
Published 2021-06-01

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

by Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
Published 2019-06-01

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

by Damien J. Downes, Robert A. Beagrie, Matthew E. Gosden, Jelena Telenius, Stephanie J. Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q. Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A. Marieke Oudelaar, Tom Brown, Veronica J. Buckle, James O. J. Davies, Jim R. Hughes
Published 2021-01-01

Reactivation of a developmentally silenced embryonic globin gene

by Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs
Published 2021-07-01