A computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescence.

by Amanda Scherer, Spencer Kuhl, Deborah Wessels, Daniel F Lusche, Brett Hanson, Joseph Ambrose, Edward Voss, Emily Fletcher, Charles Goldman, David R Soll
Published 2015-01-01

PTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-.

by Daniel F Lusche, Deborah Wessels, Nicole A Richardson, Kanoe B Russell, Brett M Hanson, Benjamin A Soll, Benjamin H Lin, David R Soll
Published 2014-01-01

Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment.

by Deborah J Wessels, Nikash Pradhan, Yang-Nim Park, Megan A Klepitsch, Daniel F Lusche, Karla J Daniels, Kayla D Conway, Edward R Voss, Suchaeta V Hegde, Thomas P Conway, David R Soll
Published 2019-01-01

Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.

by Deborah Wessels, Daniel F Lusche, Edward Voss, Spencer Kuhl, Emma C Buchele, Michael R Klemme, Kanoe B Russell, Joseph Ambrose, Benjamin A Soll, Aaron Bossler, Mohammed Milhem, Charles Goldman, David R Soll
Published 2017-01-01

Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D

by Deborah J. Wessels, Claude Pujol, Nikash Pradhan, Daniel F. Lusche, Luis Gonzalez, Sydney E. Kelly, Elizabeth M. Martin, Edward R. Voss, Yang-Nim Park, Michael Dailey, Sonia L. Sugg, Sneha Phadke, Amani Bashir, David R. Soll
Published 2021-01-01