Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

by Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Kjell Fuxe
Published 2019-09-01

Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?

by Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Kjell Fuxe
Published 2019-08-01

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

by Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Sonja Hinz, Gemma Navarro, Rafael Franco, Christa E. Müller, Kjell Fuxe
Published 2018-02-01

Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication

by Kjell Fuxe, Dasiel O Borroto-Escuela
Published 2016-01-01

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

by Manuel Narváez, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Luis Santín, Carmelo Millón, Belén Gago, Antonio Flores-Burgess, Miguel A. Barbancho, Miguel Pérez de la Mora, José Narváez, Zaida Díaz-Cabiale, Kjell Fuxe
Published 2018-05-01

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

by Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Miguel Perez De La Mora, Paul Manger, Manuel Narváez, Sarah Beggiato, Minerva Crespo-Ramírez, Gemma Navarro, Karolina Wydra, Zaida Díaz-Cabiale, Alicia Rivera, Luca Ferraro, Sergio Tanganelli, Małgorzata Filip, Rafael Franco, Rafael Franco, Kjell Fuxe
Published 2018-07-01

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

by Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Caitlin M. DuPont, Xiang Li, David Savelli, David Savelli, Davide Lattanzi, Ipsit Srivastava, Manuel Narváez, Michael Di Palma, Elisa Barbieri, Yuniesky Andrade-Talavera, Riccardo Cuppini, Yuji Odagaki, Miklos Palkovits, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Published 2017-10-01

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D₂ Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

by Lakshmi Vasudevan, Dasiel O. Borroto-Escuela, Jelle Huysentruyt, Kjell Fuxe, Deepak K. Saini, Christophe Stove
Published 2019-08-01

Adenosine A_2AReceptors in Substance Use Disorders: A Focus on Cocaine

by Karolina Wydra, Dawid Gawliński, Kinga Gawlińska, Małgorzata Frankowska, Dasiel O. Borroto-Escuela, Kjell Fuxe, Małgorzata Filip
Published 2020-06-01

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

by Dasiel O. Borroto-Escuela, Luca Ferraro, Manuel Narvaez, Sergio Tanganelli, Sarah Beggiato, Fang Liu, Alicia Rivera, Kjell Fuxe
Published 2020-04-01

On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation

by Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Alicia Rivera, Kathleen Van Craenenbroeck, Alexander O. Tarakanov, Luigi F. Agnati, Kjell Fuxe
Published 2013-01-01

Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

by Dasiel O. Borroto-Escuela, David Rodriguez, Wilber Romero-Fernandez, Jon Kapla, Mariama Jaiteh, Anirudh Ranganathan, Tzvetana Lazarova, Kjell Fuxe, Jens Carlsson
Published 2018-08-01

The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

by Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Barbara Chruścicka, Maria Lindskog, Minerva Crespo-Ramirez, Juan C. Hernández-Mondragón, Miguel Perez de la Mora, Harriët Schellekens, Kjell Fuxe
Published 2021-02-01

Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heterorecept...

by Dasiel O. Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F. Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe
Published 2016-01-01

Dopamine D4 Receptor Counteracts Morphine-Induced Changes in µ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen

by Diana Suárez-Boomgaard, Belén Gago, Alejandra Valderrama-Carvajal, Ruth Roales-Buján, Kathleen Van Craenenbroeck, Jolien Duchou, Dasiel O. Borroto-Escuela, José Medina-Luque, Adelaida de la Calle, Kjell Fuxe, Alicia Rivera
Published 2014-01-01

Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases

by Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Manuel Narvaez, Valentina Di Liberto, Sarah Beggiato, Luca Ferraro, Ramon Fores-Pons, Jose E. Alvarez-Contino, Alexander Lopez-Salas, Giuseppa Mudò, Zaida Díaz-Cabiale, Kjell Fuxe
Published 2021-07-01

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

by Dasiel O. Borroto-Escuela, Ismel Brito, Wilber Romero-Fernandez, Michael Di Palma, Julia Oflijan, Kamila Skieterska, Jolien Duchou, Kathleen Van Craenenbroeck, Diana Suárez-Boomgaard, Alicia Rivera, Diego Guidolin, Luigi F. Agnati, Kjell Fuxe
Published 2014-05-01

Existence of Brain 5‑HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5‑HT1A Receptor Recognition

by Dasiel O. Borroto-Escuela, Xiang Li, Alexander O. Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Published 2017-08-01

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

by Dasiel O. Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fuxe
Published 2018-06-01

The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine an...

by Dasiel O. Borroto-Escuela, Karolina Wydra, Ramon Fores-Pons, Lakshmi Vasudevan, Wilber Romero-Fernandez, Małgorzata Frankowska, Luca Ferraro, Sarah Beggiato, Minerva Crespo-Ramirez, Alicia Rivera, Luisa L. Rocha, Miguel Perez de la Mora, Christophe Stove, Małgorzata Filip, Kjell Fuxe
Published 2021-03-01