David M. Holtzman

David M. Holtzman is an American physician-scientist known for his work exploring the biological mechanisms underlying neurodegeneration, with a focus on Alzheimer's disease. Holtzman is former Chair of the Department of Neurology, Scientific Director of the Hope Center for Neurological Disorders, and associate director of the Knight Alzheimer's Disease Research Center at Washington University School of Medicine in St. Louis, Missouri. Holtzman's lab is known for examining how apoE4 contributes to Alzheimer's disease as well as how sleep modulates amyloid beta in the brain. His work has also examined the contributions of microglia to AD pathology. Provided by Wikipedia
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  1. 1
    Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease
    by Shannon L. Macauley, David M. Holtzman
    Published 2015-02-01
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  2. 2
    Glial contributions to neurodegeneration in tauopathies
    by Cheryl E. G. Leyns, David M. Holtzman
    Published 2017-06-01
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  3. 3
    Caspase-3 deficiency during development increases vulnerability to hypoxic–ischemic injury through caspase-3-independent pathways
    by Tim West, Madeliene Atzeva, David M. Holtzman
    Published 2006-06-01
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  4. 4
    New insights into the role of TREM2 in Alzheimer’s disease
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  5. 5
    Sleep in Alzheimer's Disease–Beyond Amyloid
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  6. 6
    Biomarkers of Alzheimer's disease
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  7. 7
    Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury
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  8. 8
    AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
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  9. 9
    Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
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  10. 10
    Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex
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  11. 11
    Lack of X-Linked Inhibitor of Apoptosis Protein Leads to Increased Apoptosis and Tissue Loss Following Neonatal Brain Injury
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  12. 12
    Diurnal oscillation of CSF Aβ and other AD biomarkers
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  13. 13
    Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition
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  14. 14
    The informed road map to prevention of Alzheimer Disease: A call to arms
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  15. 15
    Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease
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  16. 16
    Pretreatment with Human Chorionic Gonadotropin Protects the Neonatal Brain against the Effects of Hypoxic-Ischemic Injury
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  17. 17
    Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study
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  18. 18
    NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin
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  19. 19
    Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
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  20. 20
    Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease
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