Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

by Xu-Qiao Chen, William C. Mobley
Published 2019-05-01

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

by Xu-Qiao Chen, William C. Mobley
Published 2019-06-01

Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome [v1; ref status: indexed, http://f1000r.es/5ky]

by Long H. Do, William C. Mobley, Nishant Singhal
Published 2015-07-01

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

by Nadia P. Belichenko, Pavel V. Belichenko, William C. Mobley
Published 2009-04-01

Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

by Xu-Qiao Chen, Utpal Das, Gooho Park, William C. Mobley
Published 2021-03-01

Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome

by Tatsunori Takahashi, Noriaki Sakai, Tomonori Iwasaki, Timothy C. Doyle, William C. Mobley, Seiji Nishino
Published 2020-12-01

Sleep and EEG features in genetic models of Down syndrome

by Damien Colas, Janice S. Valletta, Ryoko Takimoto-Kimura, Seiji Nishino, Nobuhiro Fujiki, William C. Mobley, Emmanuel Mignot
Published 2008-04-01

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

by Alexander M. Kleschevnikov, Jessica Yu, Jeesun Kim, Larisa V. Lysenko, Zheng Zeng, Y. Eugene Yu, William C. Mobley
Published 2017-07-01

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

by Alexander M. Kleschevnikov, Pavel V. Belichenko, Jessica Gall, Lizzy George, Rachel Nosheny, Michael T. Maloney, Ahmad Salehi, William C. Mobley
Published 2012-02-01

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

by Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley
Published 2015-01-01

NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin

by David M. Holtzman, Joshua Kilbridge, David S. Bredt, Stephen M. Black, Yiwen Li, Douglas O. Clary, Louis F. Reichardt, William C. Mobley
Published 1994-11-01

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer

by Mehrdad Faizi, Patrick L. Bader, Christine Tun, Angelo Encarnacion, Alexander Kleschevnikov, Pavel Belichenko, Nay Saw, Matthew Priestley, Richard W. Tsien, William C. Mobley, Mehrdad Shamloo
Published 2011-08-01

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome

by Xu-Qiao Chen, Zhuo Xing, Quang-Di Chen, Richard J. Salvi, Xuming Zhang, Benjamin Tycko, Benjamin Tycko, William C. Mobley, Y. Eugene Yu, Y. Eugene Yu
Published 2021-07-01

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.

by April M Weissmiller, Orlangie Natera-Naranjo, Sol M Reyna, Matthew L Pearn, Xiaobei Zhao, Phuong Nguyen, Soan Cheng, Lawrence S B Goldstein, Rudolph E Tanzi, Steven L Wagner, William C Mobley, Chengbiao Wu
Published 2015-01-01

Targeted Disruption of the Cln3 Gene Provides a Mouse Model for Batten Disease

by Hannah M. Mitchison, David J. Bernard, Nicholas D.E. Greene, Jonathan D. Cooper, Mohammed A. Junaid, Raju K. Pullarkat, Nanneke de Vos, Martijn H. Breuning, Jennie W. Owens, William C. Mobley, R.Mark Gardiner, Brian D. Lake, Peter E.M. Taschner, Robert L. Nussbaum
Published 2000-04-01

Targeted Disruption of the Cln3 Gene Provides a Mouse Model for Batten Disease

by Hannah M. Mitchison, David J. Bernard, Nicholas D.E. Greene, Jonathan D. Cooper, Mohammed A. Junaid, Raju K. Pullarkat, Nanneke de Vos, Martijn H. Breuning, Jennie W. Owens, William C. Mobley, R.Mark Gardiner, Brian D. Lake, Peter E.M. Taschner, Robert L. Nussbaum
Published 1999-10-01

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.

by Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Mobley
Published 2016-01-01

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

by Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating
Published 2016-05-01