Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome

by Xu-Qiao Chen, Zhuo Xing, Quang-Di Chen, Richard J. Salvi, Xuming Zhang, Benjamin Tycko, Benjamin Tycko, William C. Mobley, Y. Eugene Yu, Y. Eugene Yu
Published 2021-07-01

Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions

by Yichen Li, Zhuo Xing, Tao Yu, Annie Pao, Marcel Daadi, Y. Eugene Yu
Published 2021-08-01

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

by Alexander M. Kleschevnikov, Jessica Yu, Jeesun Kim, Larisa V. Lysenko, Zheng Zeng, Y. Eugene Yu, William C. Mobley
Published 2017-07-01

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

by Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley
Published 2015-01-01

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

by Sheona Watson-Scales, Bernadett Kalmar, Eva Lana-Elola, Dorota Gibbins, Federica La Russa, Frances Wiseman, Matthew Williamson, Rachele Saccon, Amy Slender, Anna Olerinyova, Radma Mahmood, Emma Nye, Heather Cater, Sara Wells, Y Eugene Yu, David L H Bennett, Linda Greensmith, Elizabeth M C Fisher, Victor L J Tybulewicz
Published 2018-05-01