Engineered Swine Models of Cancer

by Adrienne L. Watson, Daniel F. Carlson, David A. Largaespada, David A. Largaespada, David A. Largaespada, David A. Largaespada, Perry B. Hackett, Perry B. Hackett, Perry B. Hackett, Scott C. Fahrenkrug
Published 2016-05-01

Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities

by Pauline J. Beckmann, David A. Largaespada
Published 2020-02-01

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors

by Kyle B. Williams, David A. Largaespada
Published 2020-04-01

Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1

by Sara H. Osum, Adrienne L. Watson, David A. Largaespada
Published 2021-02-01

Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach

by Jyotika Varshney, Milcah C. Scott, David A. Largaespada, Subbaya Subramanian
Published 2016-01-01

Flow Assisted Mutation Enrichment (FAME): A highly efficacious and efficient method to enrich Double Knockouts (DKO) after gene editing.

by Michael Hansen, Xiaopin Cai, Sara Bowen, David A Largaespada, Ming V Li
Published 2021-01-01

Sex differences in expression of immune elements emerge in children, young adults and mice with osteosarcoma

by Lauren J. Mills, Logan G. Spector, David A. Largaespada, Lindsay A. Williams
Published 2021-01-01

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

by Ami V. Patel, Katherine E. Chaney, Kwangmin Choi, David A. Largaespada, Ashish R. Kumar, Nancy Ratner
Published 2016-07-01

Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice

by Ibrahim Y. Abdelgawad, Marianne K. O. Grant, Flavia E. Popescu, David A. Largaespada, Beshay N. Zordoky
Published 2021-08-01

HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs.

by Ming V Li, Dip Shukla, Brian H Rhodes, Anjali Lall, Jingmin Shu, Branden S Moriarity, David A Largaespada
Published 2014-01-01

Neural Differentiation and Incorporation of Bone Marrow-Derived Multipotent Adult Progenitor Cells after Single Cell Transplantation into Blastocyst Stage Mouse Embryos

by C. Dirk Keene, Xilma R. Ortiz-Gonzalez, Yuehua Jiang, David A. Largaespada, Catherine M. Verfaillie, Walter C. Low P.H.D
Published 2003-04-01

Efficient Non-Viral Integration and Stable Gene Expression in Multipotent Adult Progenitor Cells

by Andrew Wilber, Fernando Ulloa Montoya, Luke Hammer, Branden S. Moriarity, Aron M. Geurts, David A. Largaespada, Catherine M. Verfaillie, R. Scott McIvor, Uma Lakshmipathy
Published 2011-01-01

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation

by Xiao-Xiao Li, Xin-Yi Lu, Shi-Jie Zhang, Amy P. Chiu, Lilian H. Lo, David A. Largaespada, Qu-Bo Chen, Vincent W. Keng
Published 2019-03-01

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

by Darius Balciunas, Kirk J Wangensteen, Andrew Wilber, Jason Bell, Aron Geurts, Sridhar Sivasubbu, Xin Wang, Perry B Hackett, David A Largaespada, R Scott McIvor, Stephen C Ekker
Published 2006-11-01

Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

by Germán L. Vélez-Reyes, Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah Berner, Madison T. Weg, Natalie K. Wolf, Susan K. Rathe, Nancy Ratner, Branden S. Moriarity, David A. Largaespada
Published 2021-03-01

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.

by Raha A Been, Michael A Linden, Courtney J Hager, Krista J DeCoursin, Juan E Abrahante, Sean R Landman, Michael Steinbach, Aaron L Sarver, David A Largaespada, Timothy K Starr
Published 2014-01-01

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

by Brandon J. Diessner, Tracy A. Marko, Ruth M. Scott, Andrea L. Eckert, Kathleen M. Stuebner, Ann E. Hohenhaus, Kim A. Selting, David A. Largaespada, Jaime F. Modiano, Logan G. Spector
Published 2019-06-01

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST

by Vincent W. Keng, Adrienne L. Watson, Eric P. Rahrmann, Hua Li, Barbara R. Tschida, Branden S. Moriarity, Kwangmin Choi, Tilat A. Rizvi, Margaret H. Collins, Margaret R. Wallace, Nancy Ratner, David A. Largaespada
Published 2012-01-01

Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

by Branden S Moriarity, Eric P Rahrmann, Dominic A Beckmann, Caitlin B Conboy, Adrienne L Watson, Daniel F Carlson, Erik R Olson, Kendra A Hyland, Scott C Fahrenkrug, R Scott McIvor, David A Largaespada
Published 2014-01-01

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.

by Aron M Geurts, Lara S Collier, Jennifer L Geurts, Leann L Oseth, Matthew L Bell, David Mu, Robert Lucito, Susan A Godbout, Laura E Green, Scott W Lowe, Betsy A Hirsch, Leslie A Leinwand, David A Largaespada
Published 2006-09-01