Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors

by Waqas Khaliq, Peter Großmann, Sophie Neugebauer, Anna Kleyman, Roberta Domizi, Sara Calcinaro, David Brealey, Markus Gräler, Michael Kiehntopf, Sascha Schäuble, Mervyn Singer, Gianni Panagiotou, Michael Bauer
Published 2020-01-01

Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or sev...

by Geoff Bellingan, David Brealey, Jordi Mancebo, Alain Mercat, Nicolò Patroniti, Ville Pettilä, Michael Quintel, Jean-Louis Vincent, Mikael Maksimow, Markku Jalkanen, Ilse Piippo, V. Marco Ranieri
Published 2017-11-01

Intensivists’ beliefs about rapid multiplex molecular diagnostic testing and its potential role in improving prescribing decisions and antimicrobial stewardship: a qualitative stud...

by Alyssa M. Pandolfo, Robert Horne, Yogini Jani, Tom W. Reader, Natalie Bidad, David Brealey, Virve I. Enne, David M. Livermore, Vanya Gant, Stephen J. Brett, the INHALE WP2 Study Group
Published 2021-06-01

Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial

by Ahilanandan Dushianthan, Howard Clark, Jens Madsen, Robin Mogg, Lewis Matthews, Lee Berry, Jorge Bernardino de la Serna, James Batchelor, David Brealey, Tracy Hussell, Joanna Porter, Ratko Djukanovic, Martin Feelisch, Anthony Postle, Michael P. W. Grocott
Published 2020-12-01

INHALE: the impact of using FilmArray Pneumonia Panel molecular diagnostics for hospital-acquired and ventilator-associated pneumonia on antimicrobial stewardship and patient outco...

by Juliet High, Virve I. Enne, Julie A. Barber, David Brealey, David A. Turner, Robert Horne, Mark Peters, Zaneeta Dhesi, Adam P. Wagner, Alyssa M. Pandolfo, Sue Stirling, Charlotte Russell, Justin O’Grady, Ann Marie Swart, Vanya Gant, David M. Livermore, INHALE Study Group
Published 2021-10-01

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

by Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard, Fabien Rebeaud, Iwan Maerki, Philippe Eggimann, Bruno François
Published 2021-04-01

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

by Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP
Published 2021-08-01