Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor.

by Anton Arkhipov, Yibing Shan, Eric T Kim, David E Shaw
Published 2014-07-01

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

by Anton Arkhipov, Yibing Shan, Eric T Kim, Ron O Dror, David E Shaw
Published 2013-07-01

Correction: Systematic Validation of Protein Force Fields against Experimental Data

by Kresten Lindorff-Larsen, Paul Maragakis, Stefano Piana, Michael P. Eastwood, Ron O. Dror, David E. Shaw
Published 2013-01-01

Systematic validation of protein force fields against experimental data.

by Kresten Lindorff-Larsen, Paul Maragakis, Stefano Piana, Michael P Eastwood, Ron O Dror, David E Shaw
Published 2012-01-01

Correction: Systematic Validation of Protein Force Fields against Experimental Data.

by Kresten Lindorff-Larsen, Paul Maragakis, Stefano Piana, Michael P. Eastwood, Ron O. Dror, David E. Shaw
Published 2013-01-01

Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations.

by Stefano Piana, Kresten Lindorff-Larsen, Robert M Dirks, John K Salmon, Ron O Dror, David E Shaw
Published 2012-01-01

An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo

by Shafaat A. Rabbani, Bushra Ateeq, Ani Arakelian, Maria Luisa Valentino, David E. Shaw, Lisa M. Dauffenbach, Christopher A. Kerfoot, Andrew P. Mazar
Published 2010-10-01

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

by Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura
Published 2021-08-01

How IGF-1 activates its receptor

by Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy
Published 2014-09-01

Quantum chemical benchmark databases of gold-standard dimer interaction energies

by Alexander G. Donchev, Andrew G. Taube, Elizabeth Decolvenaere, Cory Hargus, Robert T. McGibbon, Ka-Hei Law, Brent A. Gregersen, Je-Luen Li, Kim Palmo, Karthik Siva, Michael Bergdorf, John L. Klepeis, David E. Shaw
Published 2021-02-01

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

by Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Published 2016-10-01

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

by Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Published 2018-10-01