Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.

by Lara Moumné, Ken Campbell, David Howland, Yingbin Ouyang, Gillian P Bates
Published 2012-01-01

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

by Andreas Neueder, Christian Landles, Rhia Ghosh, David Howland, Richard H. Myers, Richard L. M. Faull, Sarah J. Tabrizi, Gillian P. Bates
Published 2017-05-01

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.

by Peter Langfelder, Fuying Gao, Nan Wang, David Howland, Seung Kwak, Thomas F Vogt, Jeffrey S Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath, X William Yang
Published 2018-01-01

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline.

by Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner
Published 2010-03-01

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

by Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Jack R Glaser, Amyaouch Bradaia, Kristian Wadel, Chrystelle Touller, Outi Kontkanen, Juha M Yrjänheikki, Bruno Buisson, David Howland, Vahri Beaumont, Ignacio Munoz-Sanjuan, Larry C Park
Published 2012-01-01

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

by Liliana Menalled, Bassem F. El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J. Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X. William Yang, Marcy MacDonald, A. Jennifer Morton, Gill Bates, Janet Leeds, Larry Park, David Howland, Ethan Signer, Allan Tobin, Daniela Brunner
Published 2009-09-01

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

by Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C Park, Sylvie Ramboz, David Howland
Published 2012-01-01

Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.

by Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Igor Filippov, Sam Miller, Mei Kwan, Michael Olsen, Jose Beltran, Justin Torello, Jon Fitzpatrick, Richard Mushlin, Kimberly Cox, Kristi McConnell, Matthew Mazzella, Dansha He, Georgina F Osborne, Rand Al-Nackkash, Gill P Bates, Pasi Tuunanen, Kimmo Lehtimaki, Dani Brunner, Afshin Ghavami, Sylvie Ramboz, Larry Park, Douglas Macdonald, Ignacio Munoz-Sanjuan, David Howland
Published 2014-01-01