Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells.

by Gregory McCarty, David M Loeb
Published 2015-01-01

Desmoplastic small round cell tumor: postoperative retroperitoneal mass

by Colette J. Shen, MD, PhD, David M. Loeb, MD, PhD, Stephanie A. Terezakis, MD
Published 2016-09-01

High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.

by Ola Awad, Jason T Yustein, Preeti Shah, Naheed Gul, Varalakshmi Katuri, Alison O'Neill, Yali Kong, Milton L Brown, Jeffrey A Toretsky, David M Loeb
Published 2010-11-01

Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.

by Ken Kikuchi, Simone Hettmer, M Imran Aslam, Joel E Michalek, Wolfram Laub, Breelyn A Wilky, David M Loeb, Brian P Rubin, Amy J Wagers, Charles Keller
Published 2014-01-01

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB

by Basia Galinski, Marcus Luxemburg, Yosef Landesman, Bruce Pawel, Katherine J. Johnson, Stephen R. Master, Kevin W. Freeman, David M. Loeb, Jean M. Hébert, Daniel A. Weiser
Published 2021-08-01

LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling

by Christopher A Scannell, Christopher A Scannell, Elisabeth A Pedersen, Jack T Mosher, Melanie Anne Krook, Lauren A Nicholls, Breelyn A Wilky, David M. Loeb, Elizabeth R Lawlor, Elizabeth R Lawlor
Published 2013-04-01

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

by Xin Huang, Haein Park, Joseph Greene, James Pao, Erin Mulvey, Sophia X Zhou, Catherine M Albert, Fred Moy, Deepali Sachdev, Douglas Yee, Christoph Rader, Carl V Hamby, David M Loeb, Mitchell S Cairo, Xianzheng Zhou
Published 2015-01-01

Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line

by Joseph Brady Moore IV, Joseph Brady Moore IV, David M Loeb, Kyung U. Hong, Poul H Sorensen, Timothy J Triche, David W Lee, Michael eBarbato, Michael eBarbato, Robert John Arceci, Robert John Arceci
Published 2015-03-01

Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma

by Jichuan Wang, Kenji Sato, Ed O'Donnell, Amit Singla, Simon Yaguare, Osama Aldahamsheh, Brian Batko, Hasibagan Borjihan, Janet Tingling, Jinghang Zhang, Daniel A. Weiser, David M. Loeb, Richard Gorlick, Edward L. Schwartz, Rui Yang, Xiaolin Zi, Hongling Zhao, David S. Geller, Bang H. Hoang
Published 2020-10-01

A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology.

by Matteo M Trucco, Ola Awad, Breelyn A Wilky, Seth D Goldstein, Ruili Huang, Robert L Walker, Preeti Shah, Varalakshmi Katuri, Naheed Gul, Yuelin J Zhu, Edward F McCarthy, Ido Paz-Priel, Paul S Meltzer, Christopher P Austin, Menghang Xia, David M Loeb
Published 2013-01-01

Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung

by Kristin Baird, John Glod, Seth M. Steinberg, Denise Reinke, Joseph G. Pressey, Leo Mascarenhas, Noah Federman, Neyssa Marina, Sant Chawla, Joanne P. Lagmay, John Goldberg, Mohammed Milhem, David M. Loeb, James E. Butrynski, Brian Turpin, Arthur Staddon, Sheri L. Spunt, Robin L. Jones, Eve T. Rodler, Scott M. Schuetze, Scott H. Okuno, Lee Helman
Published 2020-01-01