Engineering of papaya mosaic virus (PapMV) nanoparticles through fusion of the HA11 peptide to several putative surface-exposed sites.

by Gervais Rioux, Cindy Babin, Nathalie Majeau, Denis Leclerc
Published 2012-01-01

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

by Marie-Ève Lebel, Karine Chartrand, Denis Leclerc, Alain Lamarre
Published 2015-08-01

Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference

by Karine Chartrand, Marie-Ève Lebel, Esther Tarrab, Pierre Savard, Denis Leclerc, Alain Lamarre
Published 2018-01-01

A novel M2e based flu vaccine formulation for dogs.

by Denis Leclerc, Marie Rivest, Cindy Babin, Constantino López-Macias, Constantino López-Macias, Pierre Savard
Published 2013-01-01

Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity

by Marie-Eve Laliberté-Gagné, Marilène Bolduc, Caroline Garneau, Santa-Mariela Olivera-Ugarte, Pierre Savard, Denis Leclerc
Published 2021-01-01

Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform

by Marie-Ève Laliberté-Gagné, Marilène Bolduc, Ariane Thérien, Caroline Garneau, Philippe Casault, Pierre Savard, Jérome Estaquier, Denis Leclerc
Published 2019-06-01

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

by Laïla-Aïcha Hanafi, Dominique Gauchat, Jessica Godin-Ethier, David Possamaï, Jean-Baptiste Duvignaud, Denis Leclerc, Nathalie Grandvaux, Réjean Lapointe
Published 2014-01-01

Improvement of the trivalent inactivated flu vaccine using PapMV nanoparticles.

by Christian Savard, Annie Guérin, Karine Drouin, Marilène Bolduc, Marie-Eve Laliberté-Gagné, Marie-Christine Dumas, Nathalie Majeau, Denis Leclerc
Published 2011-01-01

A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling

by Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Pierre Savard, Denis Leclerc
Published 2017-07-01

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

by Omar Farnós, Alina Venereo-Sánchez, Xingge Xu, Cindy Chan, Shantoshini Dash, Hanan Chaabane, Janelle Sauvageau, Fouad Brahimi, Uri Saragovi, Denis Leclerc, Amine A. Kamen
Published 2020-11-01

A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine F...

by Joanne Langley, Elodie Pastural, Scott Halperin, Shelly McNeil, May ElSherif, Donna MacKinnon-Cameron, Lingyun Ye, Cécile Grange, Valérie Thibodeau, Jean-François Cailhier, Rejean Lapointe, Janet McElhaney, Luis Martin, Marilène Bolduc, Marie-Eve Laliberté-Gagné, Denis Leclerc, Pierre Savard
Published 2020-07-01